نتایج جستجو برای: ectopic ossification
تعداد نتایج: 32840 فیلتر نتایج به سال:
Fibrodysplasia ossificans progressiva (FOP; OMIM 135100) is a rare but extremely disabling genetic disorder of the skeletal system, and is characterized by the progressive development of ectopic ossification of skeletal muscles and subsequent joint ankylosis. The c.617G>A; p.R206H point mutation in the activin A type I receptor (ACVR1) gene has been reported to be a causative mutation of FOP. I...
Thirty-four patients wtih fibrodysplasia (syn., myositis) ossificans progressiva are described. Marked delay in diagnosis was usual, but all had characteristic skeletal malformations and ectopic ossification. The clinical features included: four types of malformation of the big toe, reduction defects of all digits, deafness, baldness of the scalp, and mental retardation. Progression of disabili...
A 3-year-old boy presented with abnormal neck posturing and rapidly growing lumps over the neck. The presence of typical malformed great toes and ectopic calcification (figure, A–C) and an affected family member confirmed the diagnosis of fibrodysplasia ossificans progressiva (FOP).1 MRI of the cervicothoracic region (figure, C, E–G) revealed diffuse hyperintense signals extending along the nec...
Ossification in the region of the posterior longitudinal ligament as a cause of cervical myelopathy.
In 1967, we operated on a patient for cervical cord compression caused by an unusual type of ectopic bone formation in the spinal canal which we tentatively identified as ossification within the posterior longitudinal ligament. Until that time we had believed that calcification of the vertebral ligaments is a phenomenon secondary to spondylosis (Oppenheimer, 1942) and does not cause symptoms by...
BACKGROUND/AIMS Joint cartilage defects are difficult to treat due to the limited self-repair capacities of cartilage. Cartilage tissue engineering based on stem cells and gene enhancement is a potential alternative for cartilage repair. Bone morphogenetic protein 2 (BMP2) has been shown to induce chondrogenic differentiation in mesenchymal stem cells (MSCs); however, maintaining the phenotypes...
Osseous choristomas are rare benign lesions characterized by ectopic bone formation in the soft tissue of the head and neck region. Dermoscopy visualizes the morphological characteristics that are not observable by the naked eye, and may be used for the evaluation of calcification under the skin. The present study reports a case of an osseous choristoma arising in the tongue, and reveals the de...
Heterotopic ossification is a condition affecting an appreciable minority of critical care patients; it can have long-lasting effects on recovery and return to functional status. Ectopic bone forms in soft tissues near the large joints, causing pain, swelling, limitation of movement and ultimate disability. X-ray changes may be delayed for several weeks after the diagnosis is clinically suspect...
Heterotopic ossification (HO) is the aberrant formation of ectopic bone within the soft tissues, of which the aetiology is usually either traumatic or neurogenic. Neurogenic HO is a known but uncommon complication that occurs after a cerebral or spinal insult. The condition may present with a spectrum of symptoms and is often difficult to diagnose clinically. Although different imaging modaliti...
Heterotopic ossification (HO) is the abnormal formation of mature bone in extraskeletal soft tissues that occurs as a result of inflammation caused by traumatic injury or associated with genetic mutation. Despite extensive research to identify the source of osteogenic progenitors, the cellular origins of HO are controversial and the underlying mechanisms, which are important for the early detec...
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