نتایج جستجو برای: edss
تعداد نتایج: 1456 فیلتر نتایج به سال:
While evoked potentials are sensitive tools for diagnosing multiple sclerosis, little is known about their prognostic value and their role in determining the course of the disease. To validate the visual and motor evoked potentials (VEP and MEP) as measures for the course of multiple sclerosis, we examined prospectively 30 patients with relapsing-remitting or secondary progressive multiple scle...
INTRODUCTION Sexual dysfunction (SD) is prevalent in multiple sclerosis (MS) patients and affects quality of life. Furthermore, lower urinary tract dysfunction (LUTD) is common in MS patients. AIMS This study aims to evaluate the relationship between SD, neurological disability, depression, anxiety, and urodynamic alterations in patients with MS and LUTD. METHODS From January 2011 to Septem...
METHOD A systematic review of the literature from 1990 to 2011 was conducted. Outcome measures included: mean cost of disease modifying therapies (DMTs), mean cost of treatment of relapses and mean cost of disease by stage stratification measured by the expanded disability status scale (EDSS). RESULTS Seven studies from three countries (Brazil, Argentina and Colombia) were included. In 2004, ...
INTRODUCTION. In multiple sclerosis (MS), patient disability is assessed according to the qualitative, ordinal Expanded Disability Status Scale (EDSS). In order to monitor treatment efficacy and disease progression, quantitative MRI metrics are sought that will correlate with EDSS [1]. In the relapsing-remitting MS (RRMS) literature, r-values for correlation with EDSS of various metrics have ra...
AIM An exploratory study of the relationship between cumulative exposure to subcutaneous (sc) interferon (IFN) β-1a treatment and other possible prognostic factors with long-term clinical outcomes in relapsing-remitting multiple sclerosis (RRMS). METHODS Patients in the original PRISMS study were invited to a single follow-up visit 15 years after initial randomisation (PRISMS-15). Outcomes ov...
OBJECTIVES Data on pregnancy long-term effects on multiple sclerosis (MS) course are still controversial; whether experiencing more than one pregnancy exposes one to risk of the disability's accrual is still unknown. We investigated differences existing in terms of disability progression among women with MS (wwMS) who had one or more children after their MS onset. METHODS Monoparous and multi...
BACKGROUND Magnetic resonance imaging (MRI) is the best biomarker of inflammatory disease activity in relapsing remitting Multiple Sclerosis (RRMS) so far but the association with disability is weak. Appearance of new MRI-lesions is used to evaluate response to immunotherapies in individual patients as well as being the most common primary outcome in phase-2 trials. Measurements of brain atroph...
Daily operation and maintenance tasks are needed to guarantee the correct performance of constructed wetlands. The definition of these activities is a complex task since these actions vary according to the characteristics of each facility. To support the definition of these operation and maintenance protocols an Environmental Decision Support System (EDSS) has been constructed (EDSS-maintenance...
Optical coherence tomography (OCT) is an emerging clinical and research measure of retinal nerve fiber layer (RNFL) loss in multiple sclerosis (MS) and may reflect neurodegeneration. Few studies capture the effect of disease duration on the RNFL in subjects without exposure to disease-modulating therapies.We assessed the relationship of RNFL loss with disease duration in subjects with untreated...
The proposed paper describes the architecture of a GIS-based Environmental Decision Support System (EDSS) that integrates software tools and sensors, such as: remote sensing for environmental monitoring and support to mathematical models, optimization models (for planning plant size, kind, and biomass harvesting), dynamic forest growth models, and models for carbon dioxide balance calculation. ...
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