OBJECTIVE To compare risk factors, treatment, and outcomes in patients with stage I/II mucinous endometrial cancer (MEC) relative to those of patients with endometrioid endometrial cancer (EEC). STUDY DESIGN We conducted a case-control study of patients with MEC and EEC. Patients with stage IA, IB, or II MEC treated at the 2 institutions between 01/01/1996 and 01/01/2007 were identified. Each...

The Protocadherin 10 (PCDH10) is inactivated often by promoter hypermethylation in various human tumors, but its possible functional role as a tumor suppressor gene is not established. In this study, we identify PCDH10 as a novel Wnt pathway regulatory element in endometrioid endometrial carcinoma (EEC). PCDH10 was downregulated in EEC tumor cells by aberrant methylation of its promoter. Restor...

BACKGROUND Endometrial cancer is the most common malignancy of the female genital tract worldwide, and endometrial endometrioid adenocarcinoma (EEC) is the major histological type of endometrial cancer. There is a great need for better markers with high sensitivity and specificity to permit early diagnosis and proper management of EEC. The aim of our study is to identify a miRNA classifier with...

Calreticulin (CALR) mutations occur in 20%-25% of myeloproliferative neoplasms (MPN). At least 40 CALR mutations have been reported to date, all located in exon 9. The most frequent CALR mutations are a 52-bp deletion (type 1) and a 5-bp insertion (type 2). Expression of type 1 CALR mutation was shown to induce constitutive activation of JAK-STAT signaling pathway in a Ba/F3-cell line with STAT...

BACKGROUND Integrative analysis of endometrioid endometrial carcinoma (EEC) using multiple platforms has distinguished four molecular subgroups. However, the landscape of expressed long non-coding RNAs (lncRNA) and their role in charting EEC subgroups and determining clinical aggressiveness remain largely unknown. RESULTS Using stringent criteria, we identified 1,931 expressed lncRNAs and pre...

Lance J. Dixon, Ming-xing Luo, Vladyslav Shtabovenko, Tong-Zhi Yang, and Hua Xing Zhu SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94039, USA Zhejiang Institute of Modern Physics, Department of Physics, Zhejiang University, Hangzhou, 310027, China The energy-energy correlation (EEC) between two detectors in e+e− annihilation was computed analytically at leading order ...

objectives: ectrodactyly-ectodermal dysplasia-clefting syndrome (eec) is a rare syndrome with features of ectrodactyly, ectodermal dysplasia and cleft lip/palate. this study presents an iranian case with classic features and oral complications.   case: we report a 20-year old female with all manifestations of this syndrome. the simultaneous presence of these three malformations is extremely rar...

The word error probability of binary linear block codes is evaluated in Rayleigh fading channels with diversity reception far three decoding algorithms: error correction (EC), errorlerasure correction (EEC). and maximum likelihood (MLI soft decoding algorithms. The performance advantage of EEC over EC In the required average SNR decreases as the number of ditersity channels increases. The perfo...

We used the methylcellulose-culture technique to determine the utility of the erythroid progenitor growth in vitro from nonadherent T-depleted bone marrow and peripheral blood cells in distinguishing polycythemia vera (PV) from essential thrombocythemia. Thirty patients with PV (group A) and 30 patients who presented with idiopathic marked thrombocytosis with platelet count greater than 1,000 x...