UNLABELLED The aim of the study was to investigate the feasibility of optimizing prophylactic dosing of factor VIII by the use of individual pharmacokinetic data. Twenty-one patients were enrolled in a randomized cross-over study on standard dosage regimens vs. dosing according to pharmacokinetic principles. The study period was 2×6 months. Using single-dose pharmacokinetic data for each patien...

A mechanical quality factor of 1.1× 107 was obtained for the 199Hz bending vibrational mode in a monocrystalline sapphire fiber at 6K. Consequently, we confirm that pendulum thermal noise of cryogenic mirrors used for gravitational wave detectors can be reduced by the sapphire fiber suspension.

Suspended monolayer transition metal dichalcogenides (TMD) are membranes that combine ultralow mass and exceptional optical properties, making them intriguing materials for opto-mechanical applications. However, the low measured quality factor of TMD resonators has been a roadblock so far. Here, we report an ultrasensitive optical readout of monolayer TMD resonators that allows us to reveal the...

Response Surface Methodology (RSM) was employed to optimise LIBS analysis of single crystal silicon at atmospheric pressure and under vacuum conditions (pressure ~10mbar). Multivariate analysis software (StatGraphics 5.1) was used to design and analyse several multi-level, full factorial RSM experiments. A Quality Factor (QF) was conceived as the response parameter for the experiments, represen...

Quality factor variation with top electrode area in thin-film barium–strontium–titanate parallel-plate capacitors is discussed. At low frequencies, the geometry dependence is consistent with the presence of a parallel parasitic loss pathway enabled by conduction over the device mesa surface. At high frequencies, the variation in the quality factor with top electrode area is due to a geometry-in...

Framed in a cognitive approach to task-supported L2 vocabulary learning, the present study used a pedagogical approach to investigate the relative effectiveness of tasks with different involvement loads on the vocabulary knowledge of Iranian EFL learners. The goal was to investigate the way that the construct of involvement load is related to the Input Hypothesis (Krashen, 1985) and the Output ...

BACKGROUND Testing technologies are increasingly used to target cancer therapies. Human epidermal growth factor receptor 2 (HER2) testing to target trastuzumab for patients with breast cancer provides insights into the evidence needed for emerging testing technologies. METHODS The authors reviewed literature on HER2 test utilization and cost effectiveness of HER2 testing for patients with bre...

Pure plasmonic mode and hybrid plasmonic mode have been demonstrated. The cone-metal shelled structure is proposed. The two modes have been examined, pure plasmonic mode and hybrid plasmonic mode. At room temperature, the quality factor of the two modes has been compared and we found that the quality factor of hybrid plasmonic mode is 775 when the side angle of the cone structure ranged (60°-70...

Purpose: The purpose of this study is to design a participatory decision-making model for teachers of the second year of secondary education in Lorestan province. In this regard, first, using library and field studies, the components of teacherschr('39') participatory decision-making were initially identified. Then, using interviews with experts and based on the Delphi method, the identified fa...