Capillary electrophoresis (CE) has become a powerful tool for enantiomer separations during the last decade. Since 1993, the author has investigated enantiomer separations by affinity capillary electrophoresis (affinity CE) with some proteins and by cyclodextrin electrokinetic chromatography (CDEKC) with some charged cyclodextrins (CDs). Many successful enantiomer separations are demonstrated f...

Citalopram is a serotonin-selective reuptake inhibitor (SSRI) widely used in the treatment of major depression and sometimes also anxiety-associated conditions, obsessive compulsive disorder and behavior disturbances associated with dementia [1, 2]. Citalopram is relatively well tolerated and has been considered to have comparatively low potential for drug–drug interactions and anti-adrenergic ...

Cisapride is a chiral molecule that is marketed as a racemate consisting of two optical isomers, but little is known about its stereoselective metabolism. Studies with (-)-, (+)-, and (+/-)-cisapride were undertaken in human liver microsomes (HLMs) and recombinant cytochrome P450s (P450s) to determine the stereoselective metabolism and enantiomer-enantiomer interaction. Each enantiomer and race...

The reactions with DNA and mutagenic activities toward Salmonella typhimurium TA 100 of the R,S,S,R and S,R,R,S enantiomers of antil,2,-dihydroxy-3,4-epoxy-l,2,3,4-tetrahydro-5-methylchrysene (anti5-MeC-l,2-diol-3,4-epoxide), an»i-5-MeC-7,8-diol-9,10-epoxide, and «nf/-6-MeC-l,2-diol-3,4-epoxide were compared because among these compounds only the H,S,S,K enantiomer of anri-5-MeC-l,2-diol-3,4e...

The front cover picture illustrates a rhodium-catalyzed enantioselective hydroacylation of racemic alkynals having substituent at the α-position carbonyl group. Mechanistic studies revealed that occurs preferentially from one enantiomer substrate via dynamic kinetic resolution (DKR) process. shows an outline DKR process by using illustration soccer, in which player getting good ball (i. e., ena...

Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.

An enantioselective synthesis of the (1S,5R)-enantiomer of litseaverticillols A and B was accomplished in line with our previously reported synthetic pathway for their (1R,5S)-enantiomer. The use of "EtSCeCl2" prepared from EtSLi and CeCl3, instead of previously employed EtSLi itself, for the formation of thiol ester intermediates prevented any undesirable epimerization occurring in the process.

Using a new sensitive reverse-phase HPLC assay relying on UV detection at 344 nm, the capacity of 18 human liver microsomal samples to support NADPH-dependent, cytochrome P450-mediated oxidation and arachidonic acid-dependent oxidation of the enantiomers of trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (B[a]P-7,8-DHD) was determined. The (-)-7R,8R-enantiomer, the preferred substrate of cytochro...