The potential role of metformin in treating endometrial cancer remains to be explored. The current study investigated the role of metformin in 17β-estradiol-induced epithelial-mesenchymal transition (EMT) in endometrial adenocarcinoma cells. We found that 17β-estradiol promoted proliferation and migration, attenuated apoptosis in both estrogen receptor (ER) positive and ER negative endometrial ...

this study was performed to identify endometrial cancer risk factors. in a case series study on 1989-1996 , we assessed endometrial cancer in 52 patients whose age range was 32-80 years, with 73% over fifty years. obesity was seen in 68% at time of cancer detection , and 69% were in the postmenopausal age, with a history of late menopause in 21%. as a matter of parity 13% were nulliparous, and ...

PURPOSE To report our experience on high-dose-rate brachytherapy (HDR-BT) in patients with stage I-III endometrial cancer unfit to surgery. MATERIAL AND METHODS Seventeen patients underwent HDR-BT as definitive treatment. Median age was 79 years (range, 60-95), median Karnofsky performance status 90% (range, 60-100). Histology was endometrial adenocarcinoma in 14 (82%), and non-endometrial in...

Objective: The authors report a rare case of uterine adenocarcinoma metastasis to both the skull base and cervical spine presenting with pathological fracture and myelopathy. Methods: We report the case of a 43-year-old Asian female with widely metastatic uterine adenocarcinoma who over the course of 3 years was diagnosed with a large clival mass and more recently a cervical spine pathological ...

Metastasis of uterine cancer to the head and neck is extremely rare. We report what we believe to be the first documented case of endometrioid adenocarcinoma metastasizing to the thyroid gland. An 80-year-old woman was referred to the otolaryngology service with a rapidly growing neck mass. The mass appeared to originate from the thyroid gland. Her clinical presentation was consistent with anap...

Abstract Endometrial carcinoma is one of the most common gynaecologic malignancies in western society. Treatment recurrent disease became more refined, with study molecular and hormonal receptors playing a central role. A 76-year-old caucasian woman presented to emergency department growing tiredness, melaena. Past medical history included an endometrioid adenocarcinoma. The patient had undergo...

Twenty-four consecutive patients with endometrial adenocarcinoma were staged pre-operatively by hysteroscopy and by fractional dilatation and curettage (D & C) to evaluate the accuracy of each method in differentiating between International Federation of Gynaecology and Obstetrics stage I and II cancer. Hysteroscopic staging was correct in 16 patients (69.6%) and incorrect in 7 (30.4%). In 1 ad...