OBJECTIVES To explore the roles of Bcl-xl and Bcl-xs in the development and progression of endometrial carcinoma, and to analyze the correlation between Bcl-xl and Bcl-xs. METHODS RT-PCR and Western-blot assay were applied to detect the expressions of Bcl-xl and Bcl-xs in endometrial tissues of various histomorphologic types. RESULTS The Bcl-xl expression levels of simple and atypical hyper...

Insulin-like growth factor-I receptor signaling contributes to the development of endometrial hyperplasia, the precursor to endometrioid-type endometrial carcinoma, in humans and in rodent models. This pathway is under both positive and negative regulation, including S6 kinase (S6K) phosphorylation of insulin receptor substrate-1 (IRS-1) at S636/639, which occurs downstream of mammalian target ...

The aim of this study is to evaluate hysterectomy procedures performed for benign conditions in terms of indications and histopatho-logical results. Retrospective analysis of 32 hysterectomy cases, which were performed between January 2011 and Decem-ber 2012, was conducted to review indications and histo-pathological diagnoses. The most frequent indications for hysterectomy were abnormal uterin...

Background: Endometrial hyperplasia (EH) is considered a heterogeneous pre-neoplastic clinical entity characterized by an abnormal glandular proliferation, with less than half of the tissue area occupied stroma. The aim this retrospective study was to evaluate correlation between histological diagnosis atypical endometrial (AEH) obtained through office hysteroscopy (OH) or uterine dilation and ...

Background: Endometrial carcinoma develops through preliminary stages of endometrial hyperplasia. A population epithelial stem cells was identified in the human endometrium, these may serve as a source putative carcinoma. The most important member cancer cell markers is OCT-4. Both tumor proliferation (Ki-67) and angiogenesis seem to be for development aggressive tumors. Aim Work: This study ai...

OBJECTIVE To investigate relapse rates after the successful treatment of patients with non-atypical endometrial hyperplasia who were randomised to either a levonorgestrel-impregnated intrauterine system (LNG-IUS; Mirena(®) ) or two regimens of oral medroxyprogesterone acetate (MPA) after primary histological response. DESIGN A multicentre randomised trial. SETTING Ten different outpatient c...

BACKGROUND Endometrial biopsies are undertaken in premenopausal women with abnormal uterine bleeding but the risk of endometrial cancer or atypical hyperplasia is unclear. OBJECTIVES To conduct a systematic literature review to establish the risk of endometrial cancer and atypical hyperplasia in premenopausal women with abnormal uterine bleeding. SEARCH STRATEGY Search of PubMed, Embase and...

Background: Management of endometrial precancerous lesions has been of much debate due to inconsistencies in their classification, natural history and histologic diagnosis. Endometrial hyperplasia constitutes a wide range of histomorphologic features associated with high intra and interobserver diagnostic variability. Although traditional microscopic diagnosis is by far the most applicable meth...

OBJECTIVE To evaluate the role of transvaginal power Doppler sonography to discriminate between benign and malignant endometrial conditions in women presenting with postmenopausal bleeding and thickened endometrium at baseline sonography. METHODS Ninety-one postmenopausal women (median age, 58 years; range, 47-83 years) presenting with uterine bleeding and a thickened endometrium (> or = 5-mm...

BACKGROUND Abnormal uterine bleeding (AUB) is the most important symptom of endometrial hyperplasia and endometrial curettage (EC) is the gold standard diagnostic procedure. We present the results of patients who underwent EC for AUB and the efficacy of progestin administration in those with endometrial hyperplasia. MATERIALS AND METHODS A total of 415 female patients who presented to Duzce P...