The concept of radicalism has been reshaping first in the rationalization of surgical procedures. For example, in endometrial cancer limited to corpus uterine , and early vulvar cancer routine lymphadenectomy is unnecessary in about 85% of cases. Thanks to the sentinel node biopsy today it is possible to indicate such intervention only in necessary cases. In the same way is has been rethinking ...

BACKGROUND Angiogenesis is essential for development, growth and advancement of solid tumors. During angiogenesis, ETS-1 is strongly expressed in vascular endothelial cells and the adjacent interstitial cells, while the inhibition of ETS-1 expression leads to suppression of angiogenesis. This prompted us to study the clinical implications of ETS-1 in relation to angiogenesis in uterine endometr...

Objective: This study aims to investigate the expression of g-synuclein in endometrioid endometrial carcinoma and assess if the g-synuclein expression correlates with the aggression of the tumour and its prognostic value in endometrioid endometrial carcinoma. Design: This retrospective study evaluated (60) specimens of the primary untreated endometrioid endometrial carcinoma and (12) normal end...

Endometrial carcinoma is the most common neoplasia of female genital tract. The prognosis of early stage disease (FIGO I and FIGO II) is excellent: recurrence after surgery is less than 15%, most of which are reported within 3 years after primary treatment. Herein we report a case of late rectal recurrence from FIGO Ib endometrial adenocarcinoma. Patient had also familiar and personal history o...

BACKGROUND Endometrial cancer is a common female malignancy. Patients with high-risk endometrial cancer have relatively high incidence of metastasis and recurrence. Despite complete resection, patients with stage III or IV are at high risk of local or distant recurrence. Systemic adjuvant treatment includes chemotherapy and radiotherapy. But the optimal scheduling is not known. Recently propose...

BACKGROUND The technique of compartment-based radical hysterectomy was originally described by M Höckel as total mesometrial resection (TMMR) for standard treatment of stage I and II cervical cancer. However, with regard to the ontogenetically-defined compartments of tumor development (Müllerian) and lymph drainage (Müllerian and mesonephric), compartments at risk may also be defined consistent...

Bowel endometriosis is the presence of ectopic endometrial glands and stroma infiltrating intestinal wall causing bowel symptoms pain. When hormonal therapies fail, surgery becomes treatment choice nowadays a minimally invasive approach standard care. We usually adopt robotic three-trocar technique with 12-mm infraumbilical camera port, two 8-mm accesses one or laparoscopic ports. Eradication d...