JUVENILE xanthogranuloma, also commonly known as naevoxantho-endothelioma, was first described as a skin disease in 1909 (McDonaugh, 1909), but it was not until forty years later that the first intra-ocular case was reported in America (Blank, Eglick, and Beerman, 1949). Some twenty to thirty cases have since been described (Sanders, 1962), but our case is the first to be reported in the United...

PF573,228 is a compound that targets focal adhesion kinase (FAK), a non-receptor protein kinase, which is over-expressed in various tumors. The aim of this study was to evaluate the effects of PF573,228 on the cells derived from mouse vascular tumors, namely, endothelioma cells. The treatment of endothelioma cells with PF573,228 reduced their growth with an IC50 of approximately 4.6 μmol L-1 an...

We have distinguished five TNF-ot-inducible cell adhesion mechanisms on microvasculature-derived endothelioma cells of the mouse which mediate the binding of different types of leukocytes. Three of these mechanisms could be identified as the mouse homologs of ICAM-1, VCAM-1, and E-selectin, of which the latter was defined by the novel mAb 21KC10. The fourth TNF-ot-inducible cell adhesion mechan...