BACKGROUND Diabetic nephropathy (DN) is a chronic microangiopathic complication of type 2 diabetes mellitus (DM).Vascular endothelial dysfunction resulting from impaired nitric oxide synthase (NOS) activity in the vascular endothelial cells has been suggested as playing an important role in the pathogenesis of diabetic nephropathy (DN). Endothelial nitric oxide synthase (E-NOS) gene G894T polym...

Sickle cell disease shows marked variability in severity and pathophysiology among individuals, probably linked to differential expression of various adhesion molecules. In this study, we investigated the differential distribution, genomic diversity and haplotype frequency of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) polymorphisms, recently implicated as important in modi...

OBJECTIVES An impaired availability of nitric oxide (NO), related to polymorphisms in endothelial nitric oxide synthase (eNOS) gene, may influence the microvasculature in systemic Sclerosis (SSc). Three potential eNOS gene polymorphisms [tandem 27-bp repeats (VNTR) in intron 4, T786C in promoter region and G894T in exon 7] were investigated to affect the susceptibility to and the clinical cours...

former SNP alters the gene responsiveness to statins: statins would up-regulate eNOS expression (2) more potently in -786C homozygous (3) and therefore, these subjects would generate more NO while on statins than subjects with the other genotypes. Accordingly, atorvastatin increased NO availability and reduced inflammatory marker concentrations in CC, but not in TT healthy men (4). However, we ...

Reported in vitro data implicated soluble CD40 ligand (sCD40L) in endothelial dysfunction and angiogenesis. However, whether sCD40L could exert that influence in endothelial dysfunction and angiogenesis after injury in acute myocardial infarction (AMI) patients remains unclear. In the present study, we evaluated the association of sCD40L with markers of platelet activation, endothelial, and vas...

Molecular-genetic diagnostics of polygenic diseases is a new and interesting area in laboratory diagnostics, especially the cardiovascular diseases, as one leading causes mortality world population.
 Aims: The aim paper was to analyse variants endothelial nitric oxide synthase gene (NOS3) (Glu298Asp/G894T) human population Tuzla Canton relation diseases.
 Study Design: study included ...