Voluntary physical exercise (wheel running, RUN) and environmental enrichment both stimulate adult hippocampal neurogenesis but do so by different mechanisms. RUN induces precursor cell proliferation, whereas ENR exerts a survival-promoting effect on newborn cells. In addition, continued RUN prevented the physiologically occurring age-related decline in precursor cell in the dentate gyrus but d...

Myocyte enhancer factors (MEF2s) bind to muscle-specific promoters and activate transcription. Drosophila Mef2 is essential for Drosophila heart development, however, neither MEF2C nor MEF2B are essential for the early stages of murine cardiomyogenesis. Although Mef2c-null mice were defective in the later stages of heart morphogenesis, differentiation of cardiomyocytes still occurred. Since the...

objective: this study designed to test the antibacterial potency of enrofloxacin (enr) and essential oils from zataria multiflora boiss (zeo) and trachyspermum copticum (teo)on aeromonas hydrophila. material and methods: the antibacterial potency of test compounds was determined by several methods including the inhibition zone diameter determination, microbroth dilution method and colorimetric ...

A competitive indirect enzyme-linked immunosorbent assay (ciELISA) using monoclonal antibodies (Mabs) having broad specificity for fluoroquinolone (FQ) antibiotics is described. Four FQs, ciprofloxacin (CIP), enrofloxacin (ENR), norfloxacin (NOR), and ofloxacin (OFL), were conjugated to bovine serum albumin for immunogens and to ovalbumin for coating antigens. A Mab C4A9H1 raised against the CI...

Abstract The use of the antibiotic enrofloxacin (ENR) in poultry is controversial. A high‐performance liquid chromatography coupled to fast‐scanning fluorescence detection (HPLC - FSFD) method for determination ENR egg white, yolk, and lyophilized samples was developed. In a first analysis, long-term administration (100 days) laying hens carried out determine its presence or both. predominance ...

Endoplasmic reticulum (ENR) stress perturbs cell homeostasis and induces the unfolded protein response (UPR). In breast cancer, this process is activated by oestrogen deprivation associated with tamoxifen resistance. We present evidence that transcription factor SOX2 long noncoding RNA overlapping transcript (SOX2OT) are upregulated in receptor-positive (ER+) cancer to deprivation. examined eff...

Malaria continues to be a major cause of children's morbidity and mortality worldwide, causing nearly one million deaths annually. The human malaria parasite, Plasmodium falciparum, synthesizes fatty acids employing the Type II fatty acid biosynthesis system (FAS II), unlike humans that rely on the Type I (FAS I) pathway. The FAS II system elongates acyl fatty acid precursors of the cell membra...

Pseudomonas aeruginosa is an opportunistic pathogen which is responsible for a wide range of infections. Production of virulence factors and biofilm formation by P. aeruginosa are partly regulated by cell-to-cell communication quorum-sensing systems. Identification of quorum-quenching reagents which block the quorum-sensing process can facilitate development of novel treatment strategies for P....

Enrofloxacin (ENR) belongs to the fluoroquinolone (FQ) antibiotics family, which are contaminants of emerging concern frequently found in effluents. Although many works studying photo-Fenton process for FQ degradation have been reported, there no reports analysing deep effect iron complexation, as well other metals, towards FQs’ photolysis, which, evidently, also contributes overall pollutant. ...