BACKGROUND In the rat brain, context information is thought to engage network interactions between the postrhinal cortex, medial entorhinal cortex, and the hippocampus. In contrast, object information is thought to be more reliant on perirhinal cortex and lateral entorhinal cortex interactions with the hippocampus. METHOD The 'context network' was explored by mapping expression of the immedia...

Brain region coordination in learning Gamma-frequency oscillations have been hypothesized as a physiological mechanism of interregional communication the brain. However, until now, all supporting data correlational and thus indirect. Fernández-Ruiz et al. examined gamma-frequency activity spike coupling between entorhinal cortex hippocampal dentate gyrus during after selective perturbation timi...

Neurons in the medial entorhinal cortex fire action potentials at regular spatial intervals, creating a striking grid-like pattern of spike rates spanning the whole environment of a navigating animal. This remarkable spatial code may represent a neural map for path integration. Recent advances using patch-clamp recordings from entorhinal cortex neurons in vitro and in vivo have revealed how the...

The entorhinal cortex plays an important role in spatial memory and episodic memory functions. These functions may result from cellular mechanisms for integration of the afferent input to entorhinal cortex. This article reviews physiological data on persistent spiking and membrane potential oscillations in entorhinal cortex then presents models showing how both these cellular mechanisms could c...

This review is focused on specific circuits of the medial temporal lobe that have become better understood in recent years for their computational properties contributing to episodic memory and to memory impairment associated with aging and other risk for AD. The layer II neurons in the entorhinal cortex and their targets in the dentate gyrus and CA3 region of hippocampus comprise a system that...

Entitled: Muscarinic suppression of excitatory synaptic responses in layer II of the entorhinal cortex and submitted in partial fulfillment of the requirements for the degree of Masters of Psychology complies with the regulations of the University and meets the accepted standards with respect to originality and quality. The entorhinal cortex is thought to play a role in mechanisms mediating sen...

OBJECTIVE Microinjectin of neostigmine, an inhibitor of acetylcholine esterase, into the rat hippocampus elicited stress-like responses reflected by the release of adrenocorticotropic hormone (ACTH) and blood glucose elevations. The entorhinal cortex is regarded as an interface between the hippocampus and neocortex. The current study was designed to examine the role of the entorhinal cortex in ...

To understand the structural basis of grid cell activity, we compare medial entorhinal cortex architecture in layer 2 across five mammalian species (Etruscan shrews, mice, rats, Egyptian fruit bats, and humans), bridging ∼100 million years of evolutionary diversity. Principal neurons in layer 2 are divided into two distinct cell types, pyramidal and stellate, based on morphology, immunoreactivi...

Entorhinal verrucae are unique, small elevations on the surface of entorhinal cortex, formed due to distinctive clustering of large neurons in entorhinal layer II. In Alzheimer’s disease, the verrucae atrophy as a result of neurofibrillary tangle formation and concomitant neuronal loss. Previously, we found significant decreases in verrucae height, width, surface area, and volume even in the mi...