The use of natural polymers in the drug delivery continues to be an area of intensive research despite the advent of several new synthetic polymers. The present study envisages pharmaceutical utility of Assam glutinous rice as natural biopolymeric matrix for microfabricated controlled DDS. Microcarriers were prepared using an industrially feasible ionic gelation method using the blends of propo...

Aim: The objective of the present study is to design and evaluate mucoadhesive microspheres for oral controlled release. Materials and Method: Rosiglitazone maleate microspheres with a coat consisting of alginate and a mucoadhesive polymer sodium carboxymethylcellulose, carbopol 934P and hydroxypropylmethylcellulose were prepared by an orifice-ionic gelation process. The microspheres were evalu...

The present study was planed to prepare microspheres for sustained release of Lamivudine using various cellulose polymers such as Ethyl cellulose, Cellulose acetate phthalate, cellulose acetate by employing solvent evaporation technique. Microspheres were characterized for the particle size distribution, wall thickness by scanning electron microscopy (SEM), angle of repose, drug content, bulk d...

Niosomes have potential applications in topical drug delivery system. The objective of the study was to formulate and evaluate the niosome of Itraconazole. Surfactant : cholesterol ratio and quantity of ethanol used were studied by applying factorial design. Formulated niosomes were evaluated for vesicle size, entrapment efficiency, drug release, skin permeation, and antimycotic activity. Vesic...

Liquid crystalline nanoparticles are unique structures that can be used in the delivery of a wide range of pharmaceutical actives. Herein, we studied the effect of saturated fatty acids on tacrolimus-loaded monoolein liquid crystalline nanoparticles stabilized with poloxamer 407. Characterization of nanoparticles included optical and transmission electron microscopy, particle size, and entrapme...

The present study describes the preparation of a carrier system based on zinc-alginate beads and to evaluate its potential for the controlled release of rifampicin, the poorly water soluble drug using ionic gelation technique. The surface topology of the developed beads were analyzed by Scanning Electron Microscopy and the crosslinking process was investigated by Fourier Transform. Infrared spe...

The aim of present study was to formulate and evaluate nanoparticles of acyclovir by using different hydrophilic polymers. Acyclovir was selected as a suitable drug for gastroretentive nanoparticles due to its short half life, low bioavailability, high frequency of administration, and narrow absorption window in stomach and upper part of GIT. The nano-precipitation method was used to prepare na...

The complex nanoliposomes encapsulating both a hydrophilic drug vitamin C (vit C) and hydrophobic drug medium-chain fatty acids (MCFAs) was prepared by combining double emulsion method with dynamic high pressure microfluidization. The complex nanoliposomes was further freeze-dried under -86 °C for 48 h with sucrose at the sucrose/lipids ratio of 2:1(w/w) in order to enhance its stability. The f...

Oral gastroretentative dosage forms offer many advantages for drugs having absorption from upper gastrointestinal tract and improve the bioavailability of medication that is characterized by narrow absorption window. The purpose of present study was to formulate and develop a new gastroretentative controlled release diffusion of furosemide from the cellulose acetate floating microspheres. Furos...