PURPOSE Medical students are traditionally taught the physical exam as a comprehensive battery of maneuvers, yet they express uncertainty about which maneuvers are "core" and should be performed routinely on patients and which ones should be performed only when clinically indicated. The authors sought to determine whether educator consensus existed on the concept and the specifics of a core phy...

KIF3C is one subunit of the functional microtubule-based kinesin-2 KIF3AC motor, an anterograde cargo transporter in neurons. However, KIF3C has also been implicated as an injury-specific kinesin that is a key regulator of axonal growth and regeneration by promoting microtubule dynamics for reorganization at the neuronal growth cone. To test its potential role as a modulator of microtubule dyna...

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A key question in understanding microtubule dynamics is how GTP hydrolysis leads to catastrophe, the switch from slow growth to rapid shrinkage. We first provide a review of the experimental and modeling literature, and then present a new model of microtubule dynamics. We demonstrate that vectorial, random, and coupled hydrolysis mechanisms are not consistent with the dependence of catastrophe ...

In today’s world we are living in an age where disposables have become a way of life. In this “use and throw” society, plastics have become a part of our day to-day lifestyle, and affect everyone. Plastics have several drawbacks, and also contain toxins that can trigger the development of cancerous diseases. The hospital today is on the brink of a progressing ecological catastrophe. Excessive u...

A semiclassical wave packet propagating in a dissipationless Fermi gas inevitably enters a "gradient catastrophe" regime, where an initially smooth front develops large gradients and undergoes a dramatic shock-wave phenomenon. The nonlinear effects in electronic transport are due to the curvature of the electronic spectrum at the Fermi surface. They can be probed by a sudden switching of a loca...

A total of 132 strains of anaerobic bacteria were tested for susceptibility to josamycin, using a broth dilution technique. All strains of Peptococcus species, Peptostreptococcus species, and Bacteroides fragilis were inhibited by 2 mug or less per ml. Seventy percent of these susceptible strains were also killed by 2 mug or less of josamycin per ml. However, 2 of 12 Clostridium species and 6 o...