Natural products have a wide range of diversity multidimensional chemical structures which play vital role show the important nature as golden source for achieving herbal drug discovery. Literature survey was accomplished using multiple databases including PubMed, Science Direct, ISI web knowledge and Google Scholar. Epigallocatechin-3-gallate is most abundant tea polyphenol, followed by other ...

  Abstract   Introduction: Neurodegeneration change is one of the hallmark symptoms of which Alzheimer’s disease (AD) can be modeled by β-amyloid injection into specific regions of brain. (-)-Epigallocatechin-3-gallate (EGCG) is a potent antioxidant agent that its role against oxidative stress and inflammation has been shown in prior studies. In the present study, we have wanted to determine wh...

(-)-Epigallocatechin gallate (EGCG) and (-)-epigallocatechin (EGC) are the major polyphenolic constituents in green tea. In this study, we characterized the enzymology of cytosolic catechol-O-methyltransferase (COMT)-catalyzed methylation of EGCG and EGC in humans, mice, and rats. At 1 microM, EGCG was readily methylated by liver cytosolic COMT to 4"-O-methyl-EGCG and then to 4',4"-di-O-methyl-...

Objective(s): In the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (EGCG) on lipopolysaccharide (LPS)-induced hepatotoxicity by using Hep3B human hepatoma cells. Specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of LPS-associated cytotoxicity. Consequently, the hepatocellu...

Potential effects of tea and its constituents on SARS-CoV-2 infection were assessed in vitro. Infectivity was decreased to 1/100 undetectable levels after a treatment with black tea, green roasted or oolong for 1 min. An addition (−) epigallocatechin gallate (EGCG) significantly inactivated SARS-CoV-2, while the same concentration theasinensin A (TSA) galloylated theaflavins including theaflavi...

Though the instability of polyphenols in cell culture experiment has been investigated previously, underlying mechanism is not completely clear yet. Therefore, this study, stability epigallocatechin gallate (EGCG) medium DMEM was at 4 °C and 37 via UPLC-MS-MS analysis followed by determination antioxidant capacity EGCG. EGCG instable formed various degradation products derived from its dimer wi...

BACKGROUND Condyloma acuminatum (CA) is one of the most common sexually transmitted diseases and induced by low-risk human papillomaviruses (HPVs), mainly HPV type 6 and 11. Here, we report the identification of (-)-Epigallocatechin-3-gallate (EGCG) by an HPV11 infection cell model. RESULTS The recombined HPV11.HaCaT cells had stable HPV 11 early genes expression. The introducing of HPV11 gen...

Tea has been shown to inhibit chemically induced tumorigenesis in many animal models, but the effects of tea consumption on human carcinogenesis are not conclusive. In order to develop biomarkers for tea consumption, we developed methods for the analysis of tea polyphenols in human plasma and urine samples using HPLC with the coulochem electrode array detection system. (-)-Epigallocatechin-3-ga...

We have applied surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using titanium dioxide nanoparticles (TiO2 NPs) as the matrix and captopril (CAP) as internal standard for the determination of the concentrations of theanine and four catechins—catechin, ()-epigallocatechin (EGC), ()-epicatechin gallate (ECG), and ()-epigallocatechin gallate (EGCG). Under the optimal cond...

Despite numerous previous studies, the mechanism of the free radical interaction between alpha-tocopherol (VE), or ascorbate and flavonoids, as coantioxidants remains unclear. The synergistic antioxidant effects of VE or L-ascorbyl 2,6-dibutyrate (ASDB, an ascorbate derivative) with the flavonoids (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG) and (-)-epigalloca...