Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection (STI) gonorrhea, is a growing public health threat for which a vaccine is urgently needed. We characterized the functional role of the gonococcal MetQ protein, which is the methionine binding component of an ABC transporter system, and assessed its potential as a candidate antigen for inclusion in a gonococcal vacc...

The constant self renewal and differentiation of adult intestinal stem cells maintains a functional intestinal mucosa for a lifetime. However, the molecular mechanisms that regulate intestinal stem cell division and epithelial homeostasis are largely undefined. We report here that the small GTPases Cdc42 and Rab8a are critical regulators of these processes in mice. Conditional ablation of Cdc42...

Mammalian cell cytoplasmic RNA stress granules are induced during various conditions of stress and are strongly associated with regulation of host mRNA translation. Several viruses induce stress granules during the course of infection, but the exact function of these structures during virus replication is not well understood. In this study, we showed that respiratory syncytial virus (RSV) induc...

calcifying epithelial odontogenic tumor is a rare odontogenic neoplasm. its occurrence in the maxillary sinus is very rare. maxillary tumors tend to be locally aggressive and may rapidly involve the surrounding vital structures.  we report a case of calcifying epithelial odontogenic tumor involving maxillary sinus in a 48 years old female patient with the oral mucosal involvement. the purpose o...

purpose: to report two cases of secondary epithelial iris cyst (seic) with pus-like precepitates in the cyst. patients and findings: two young men with history of penetrating trauma to the eye and primary repair developed secondary epithelial iris cyst several years later. slit-lamp biomicroscopy revealed a large cyst originating from the site of the laceration. the cyst was filled with pus-lik...

primary splenic cyst is a rare entity and majority of the cases are classified as epithelial cysts. they are uncommon, comprising only about 10% of benign non-parasitic cysts. most of the cysts are asymptomatic, and they are incidental findings during abdominal ultrasonography. we report a case of 20 years old male who presented with 1 year history of mild abdominal pain and left upper quadrant...

Benign epithelial inclusions present in sentinel lymph nodes a diagnostic challenge, particularly at frozen section, and can be mistaken for metastatic malignancy. Heterotopic breast tissue axillary is well documented,1 as its potential proliferative changes including papillomas.2 Also described the concept of iatrogenic cell displacement complication needle procedures contributing to lesions w...

Chlamydiae are obligate intracellular pathogens replicating only inside the eukaryotic host. Here, we studied the effect of human flotillin-1 protein on Chlamydia pneumoniae growth in human line (HL) and A549 epithelial cell lines. RNA interference was applied to disrupt flotillin-1-mediated endocytosis. Host-associated bacteria were detected by quantitative PCR, and C. pneumoniae growth was ev...

In vivo corneal replicas were made in 20 cases of patients with superficial dendritic ulcers of the cornea. Histopathological study of the replicas and superficial epithelial cells showed that the dendrites are composed of rounded epithelial cells and variable sized syncytia containing bizarre shaped nuclei. Pseudopodia-like processes containing DNA and some RNA extend from the syncytia into th...