The generation of an organized architectural pattern during tissue formation is a process of paramount importance during development and organogenesis. A large proportion of the vertebrate body is made of epithelial tissues; these provide organized barriers between organ compartments and also differentiate into glandular, secretory specializations (Kahata et al., 2017). One feature of epithelia...

Cell fate determination is a major unsolved problem in cell and developmental biology. The discovery of reprogramming by pluripotent factors offers a rational system to investigate the molecular mechanisms associated with cell fate decisions. The idea that reprogramming of fibroblasts starts with a mesenchymal-epithelial transition (MET) suggests that the process is perhaps a reversal of epithe...