purpose: to report a case of isolated corneal squamous cell intraepithelial neoplasia in a patient with unilateral dry eye symptoms. case report: a 48 year old man presented with history of thermal corneal injury in his left eye two years ago, with decreased visual acuity and dry eye symptoms a short time thereafter. he was treated for dry eye with no improvement in symptoms. upon presentation,...

The role of miRNA processing in the maintenance of adult pancreatic acinar cell identity and during the initiation and progression of pancreatic neoplasia has not been studied in detail. In this work, we deleted Dicer specifically in adult pancreatic acinar cells, with or without simultaneous activation of oncogenic Kras. We found that Dicer is essential for the maintenance of acinar cell ident...

Thymic epithelial tumors (TETs) comprise a heterogeneous group of epithelial-derived thymic neoplasms with diverse clinical behavior and underlying molecular genetic features. Owing to their rare nature, the classification TETs has only recently begun be fully explored. The advent advanced studies, particularly ability sequence DNA RNA in massively parallel fashion, led an increased understandi...

Fifty women attending a clinic for sexually transmitted diseases with vulval condylomata acuminata were examined by cervical cytology and colposcopy for cervical infection by human papillomavirus (HPV) or epithelial abnormality indicating cervical intraepithelial neoplasia (CIN) or both. Collated results showed a high prevalence of both conditions in these 50 women; 25 (50%) had evidence of cer...

Thymic epithelial tumors occur in 1-5% of patients with multiple endocrine neoplasia type 1 (MEN 1). Majority of these thymic epithelial tumors are thymic carcinoids and patients with thymoma in MEN 1 is rare. Furthermore, thymoma with neuroendocrine differentiation was also rarely reported. Herein, we report a 68-year-old man having type B3 thymoma with neuroendocrine differentiation in MEN 1 ...

Cervical carcinoma is the second leading cancer in women in Malaysia, after breast cancer. Human papillomavirus (HPV) has been implicated in the development of dysplasia or cervical intraepithelial neoplasia and progression to squamous cell carcinoma. Because of the confinement of the human papillomavirus infection within the epithelial layer, the presence of dentritic cells or Langerhans cells...

Aim: To find the clinical association of cervical cancer with pap smear test. Study Design: Prospective study Place and Duration Study: Department Obstetrics & Gynaecology, AJK Medical College Muzaffarbad Azad Kashmir from 1st January 2021 to 30th June 2022. Methodology: Five hundred women were screened who between 20-55 years age. Sampling was performed by ecto-cervix through wooden Ayre s...

Introduction and Aim: Stromal malignancies of uterus are rare accounts for 1-3% all female genital tract malignancies. They known to pose a diagnostic challenge the clinicians pathologists. show non-specific clinical features, gross appearance, varying histological immunohistochemical features. This study highlights important clinical, morphologic features these tumors. Methodology: Histopathol...