BACKGROUND The aim of the study was to clarify the effect of p53 status of tumor cells on radiosensitivity of solid tumors following accelerated carbon-ion beam irradiation compared with γ-rays or reactor neutron beams, referring to the response of intratumor quiescent (Q) cells. METHODS Human head and neck squamous cell carcinoma cells transfected with mutant TP53 (SAS/mp53) or with neo vect...

The radioisotope Technetium-99m (99mTc) is used in 85% of all nuclear medicine procedures. 99mTc is produced from its precursor Molybdenum-99 (99Mo), whose production is nearly all from one of only five ageing research reactors. Recently a number of accelerator-based methods have been proposed to fill this gap and to diversify this supply chain. In this paper we present a compact (4 m) 10 mA, 3...

The radioisotope Technetium-99m (99mTc) is used in 85% of all nuclear medicine procedures. 99mTc is produced from its precursor Molybdenum-99 (99Mo), whose production is nearly all from one of only five ageing research reactors. Recently a number of accelerator-based methods have been proposed to fill this gap and to diversify this supply chain. In this paper we present a compact (4 m) 10 mA, 3...

The observance of parity conserving time reversal violation in light quark systems could signal the presence of physics beyond the Standard Model. I discuss the implications of low-energy time reversal tests for the existence of such T-violating, P-conserving (TVPC) interactions. I argue that searches for permanent electric dipole moments (EDM’s) and direct TVPC searches provide complementary i...

Boron Neutron Capture Therapy (BNCT) is a rather innovative cancer radiotherapy; at present it is object of increasing interest especially for treatment of those tumors where conventional therapy gives not satisfactory results (Glioblastoma and Malignant Melanoma). The therapy takes advantage of both chemical and physical aspects B: the possibility of selectively accumulating in tumor tissue th...

Introduction: Many photogeologic studies and very recent results from orbital geochemical mapping experiments are consistent with the presence of shallow subsurface ice deposits on Mars. The next step in studying these deposits will be to visit them on the surface, probably with mobile robotic explorers. In order for such rover missions to be successful, they must carry instruments capable of i...

Introduction: Epithermal neutrons provide a robust measure of hydrogen abundance and have been used on many planetary bodies to measure hydrogen enhancements [e.g. 1,2,3,4]. Lunar polar epithermal neutrons display a strong, statistically significant, offpolar enhancement that is not clearly explainable by the current thermal environment. One plausible explanation is that these enhancements repr...

background: in neutron interaction with matter and reduction of neutron energy due to multiple scatterings to the thermal energy range, increasing the probability of thermal neutron capture by neutron captures makes dose enhancement in the tumors loaded with these materials.   objective: the purpose of this study is to evaluate dose distribution in the presence of  10 b ,  157 gd  and  33 s  ne...

Orbital measurements of neu tro ns by the Lunar Explori ng Neutron Detector (LEN D) onboard the Lunar Reconnaissance Orbiter are being used to quantify the spatial dis tribution of near surface hydrogen (H). In fe rred H concentration maps have low signal-to-noise (SN) and image restoration (IR) techniques are being studied to enhance results. A single-blind. two-phase study is described in whi...