In this paper, we justify the hydrostatic approximation of primitive equations in maximal $$L^p$$ - $$L^q$$ -settings three-dimensional layer domain $$\varOmega = \mathbb {T} ^2 \times (-1, 1)$$ under no-slip (Dirichlet) boundary condition any time interval (0, T) for $$T>0$$ . We show that solution to $$\epsilon $$ -scaled Navier–Stokes with Besov initial data $$u_0 \in B^{s}_{q,p}(\varOmega )...

Venezuelan equine encephalitis virus (VEE) produces an acute infection in humans and induces a well-characterized cytopathic effect in neurons of the central nervous system (CNS). However, little is known about the role of glial cells in response to VEE infection of the CNS. Our results demonstrate that VEE is capable of a productive infection in primary astrocyte cultures and that this infecti...

Endocytic trafficking is a critical mechanism for cells to decode complex signaling pathways, including those activated by G-protein-coupled receptors (GPCRs). Heterogeneity in the endosomal network enables GPCR activity to be spatially restricted between early endosomes (EEs) and the recently discovered endosomal compartment, the very early endosome (VEE). However, the molecular machinery driv...

Venezuelan equine encephalitis virus (VEEV) is an emerging pathogen of equids and humans, but infection of its rodent reservoir hosts has received little study. To determine whether responses to infection vary among geographic populations, we inoculated 3 populations of cotton rats with 2 enzootic VEEV strains (Co97-0054 [enzootic ID subtype] and 68U201 [enzootic IE subtype]). The 3 populations...

The notion of (∈,∈ ∨q)-interval-valued fuzzy prime ideals in commutative BCK-algebras is introduced. Some characterization theorems in (∈,∈ ∨q)-interval-valued fuzzy prime ideals in commutative BCK-algebras are derived. Also we study relation between (∈,∈ ∨q)-interval-valued fuzzy prime ideal and (∈ ∨q)-interval-valued fuzzy level prime ideals. Characterization of interval-valued fuzzy set to b...

Recent years have witnessed a surge of interest the lensing black holes arising from general as well other modified theories gravity due to experimental data available Event Horizon Telescope (EHT) results. The EHT may open new door indicating possible existence rotating hole solutions in strong field regime. With this motivation, we investigate present paper equatorial $(\ensuremath{\theta}=\e...

Venezuelan equine encephalitis (VEE) is reemerging in Peru. VEE virus subtype ID in Peru has not been previously associated with severe disease manifestations. In 2006, VEE virus subtype ID was isolated from a boy with severe febrile disease and gastrointestinal bleeding; the strain contained 2 mutations within the PE2 region.

One of the most important questions in arbovirology concerns the origin of epidemic Venezuelan equine encephalitis (VEE) viruses; these viruses caused periodic, extensive epidemics/epizootics in the Americas from 1938-1973 (reaching the United States in 1971) but had recently been presumed extinct. We have documented the 1992 emergence of a new epidemic/epizootic VEE virus in Venezuela. Phyloge...

An epitope-blocking enzyme-linked immunosorbent assay was developed for the rapid differentiation of serologic responses to enzootic variety IE and ID versus epizootic variety IAB and IC strains of Venezuelan equine encephalitis (VEE) virus. Two monoclonal antibodies that differentially recognize epizootic versus enzootic VEE virus epitopes were used to measure the serotype-specific blocking ab...