Three antimalarial drugs, artesunate, pyrimethamine, and pamaquine, were evaluated for their growth-inhibitory effects against Babesia equi and Babesia caballi in in vitro culture. B. equi was more resistant to pyrimethamine than B. caballi. B. equi was also found to be more sensitive to artesunate and pamaquine than B. caballi. Of the three compounds, pyrimethamine gave the most promise for in...

Rhodococcus equi is a facultative intracellular bacterium causing severe pyogranulomatous pneumonia, ulcerative enterocolitis, and mesenteric lymphadenopathy in foals aged less than 6 months. Less frequently, this pathogen affects various other species, such as pigs, cattle, cats, and even humans. Although rhodococcosis is treated with a combination of antimicrobial agents, resistance is develo...

Theileria equi has a biphasic life cycle in horses, with a period of intraleukocyte development followed by patent erythrocytic parasitemia that causes acute and sometimes fatal hemolytic disease. Unlike Theileria spp. that infect cattle (Theileria parva and Theileria annulata), the intraleukocyte stage (schizont) of Theileria equi does not cause uncontrolled host cell proliferation or other si...

BACKGROUND Rhodococcus equi is an important pathogen of foals. Enteral administration of live, virulent R. equi during early life has been documented to protect against subsequent intrabronchial challenge with R. equi, indicating that enteral mucosal immunization may be protective. Evidence exists that mucosal immune responses develop against both live and inactivated micro-organisms. The exten...

Rhodococcus equi is an important pathogen of foals, causing severe pyogranulomatous pneumonia. Virulent R. equi strains grow within macrophages, a process which remains poorly characterized. A potential source of carbon for intramacrophage R. equi is membrane lipid-derived fatty acids, which following beta oxidation are assimilated via the glyoxylate bypass. To assess the importance of isocitra...

Rhodococcus equi is a major cause of pneumonia in domestic animals, especially foals, and an opportunistic pathogen of immunocompromised humans (1). Control of R. equi infections in horses has relied on early detection of subclinical pulmonary disease and treatment with antimicrobial drugs before development of clinical signs (2). However, the onset of clinical signs of R. equi pneumonia in foa...

Rhodococcus equi is an emerging opportunistic pathogen in immunocompromised patients. A lungtransplant recipient developed weight loss, nonproductive cough, dyspnea, and somnolence. Computed tomogram showed a pulmonary nodule and pleural changes in the right allograft that was due to R. equi infection. Alteration of cell-mediated immunity is a predisposing risk factor for R. equi infection in h...

Rhodococcus equi infection is commonly encountered in HIV-infected patients; recipients of organ transplants; and in those with lymphoma, chronic renal failure, alcoholism, lung cancer, leukaemia, diabetes mellitus, and other states of immunodeficiency. Recent reports have also documented R. equi infections among immunocompetent patients. The most common manifestations of R. equi infections are...

We consider the problem of clustering a set of items into subsets whose sizes are bounded from above and below. We formulate the problem as a graph partitioning problem and propose an integer programming model for solving it. This formulation generalizes several well-known graph partitioning problems from the literature like the clique partitioning problem, the equi-partition problem and the k-...

Rhodococcus equi, a gram-positive facultative intracellular pathogen, is one of the most common causes of pneumonia in foals. Although R. equi can be cultured from the environment of virtually all horse farms, the clinical disease in foals is endemic at some farms, sporadic at others, and unrecognized at many. On farms where the disease is endemic, costs associated with morbidity and mortality ...