264 The Journal of Clinical Pharmacology T HE effects of dosage form variables on therapeutic efficacy and/or bioavailability of drugs are well documented.m Usually, these effects will be manifest principally in differences in rate of absorption and/or differences in efficiency of absorption. Since a formulation which releases a drug slowly over an extended time could have the same bioavailabil...

Fourteen patients with acute myocardial infarction were given 0.3 mg sublingual nitroglycerin within the first 12 hours of their acute myocardial infarction. Five minutes after sublingual nitroglycerin mean arterial pressure fell 9 mmHg (1.2 kPa) and remained significantly reduced for 30 minutes. Pulmonary capillary wedge pressure fell from a mean control value of 17 to 12 mmHg (2.3 to 1.6 kPa)...

intermittent drying is a satisfactory technique for drying of heat sensitive grains especially rough rice. this method consists of two separate stages applied intermittently: drying and tempering. in this work, intermittent drying of rough rice is investigated both theoretically and experimentally. in order to characterize this process; a multi-scale model consisting of macroscopic and microsco...

INTRODUCTION Delayed gastric emptying occurs frequently in critically ill patients and has the potential to adversely affect both the rate, and extent, of nutrient absorption. However, there is limited information about nutrient absorption in the critically ill, and the relationship between gastric emptying (GE) and absorption has hitherto not been evaluated. The aim of this study was to quanti...

Glucagon was administered to I3 infants and children with advanced atrioventricular block. The drug produced a positive response in 12 children when given intravenously in a dose of oo2-o o5 mg/kg. Ventricular rate rose approximately 20 per cent. Cardiac output rose in each of the 4 patients so tested. Onset of action was within 3 minutes. Though the duration of response lasted nearly 20 minute...

BACKGROUND Ibuprofen and paracetamol differ in their mode of action and related therapeutic effects, suggesting that combined administration may offer improved analgesia. Reported here are the results of two studies on the pharmacokinetic properties of a novel ibuprofen (200 mg) and paracetamol (500 mg) fixed-dose combination tablet. METHODS Both studies were open-label, randomised studies in...

abstract main objective of this paper is to investigate the impact of exchange rate misalignment on wheat’s producer estimates (pse), using the 1989-2007 period’s data. for this purpose, vector error correction model (vecm) along with the use of real exchange rate based on purchasing power party (ppp) was applied to estimate nominal equilibrium exchange rates. then, by using market price suppor...

for the purpose of increasing the permeability to oxygen and equilibrium water content in contact lenses, polar copolymers with nonionic monomers such as 2-hydroxyethle methacrylate(hema) is used. by adding the polar monomers to (hema), the permeability to oxygen and equilibrium with water content is increased and also the absorption of proteins on lens surface is changed. in this research, the...

there are various ways for estimating velocity of money in economic literature and each has its own specific weaknesses and strengths. particularly, since a great deal of financial innovations and changes have recently taken place affecting the velocity of money, many traditional methods can no langer calculate the equilibrium velocity of money, and they are no longer dependable from the econom...