Noninvasive imaging of ventricular activation is of great importance in cardiovascular research and clinical diagnosis of cardiac diseases. Three-dimensional (3-D) cardiac activation imaging (3-DCAI) is a biophysical model based approach that aims at imaging the activation sequence throughout the entire myocardium. In the present study, the performance of 3-DCAI was evaluated through in vivo pa...

PURPOSE To clarify the neurophysiological mechanism of epileptic negative myoclonus (NM) of a patient with atypical benign partial epilepsy whose NM was completely suppressed with ethosuximide. METHODS Polygraphic recordings of whole-head type magnetoencephalography (MEG), EEG and electromyography were made during NM of the bilateral hands. The silent period of 200-400 ms duration in the bila...

Head movements during magnetoencephalography (MEG) recordings may lead to inaccurate localization of brain activity. This can be particularly problematic for studies with children. We quantified head movements in 8- to 12-year-old children performing a cognitive task and examined how the movements affected source estimation. Each child was presented auditory word stimuli in five 4-min runs. The...

BACKGROUND Studies have shown that antibodies targeting the intracellular (ICD) or extracellular domains (ECD) of human epidermal growth factor receptor 2 (HER2) are equivalent when traditional methods are used. We describe a new method to quantify ICD and ECD expression separately and assess the prognostic value of domain-specific HER2 results in patients who received adjuvant trastuzumab ther...

1 Introduction Selecting the surgical candidate for medically intractable epilepsy, detection and localization of seizure focus and cerebral functions are essential for diagnosis, for localization of surgical treatment and for prevention of surgical complications. Due to the limitations of noninvasive evaluations, invasive examinations, such as chronic ECoG grid recording, cortical stimulation ...

We developed a new estimation method for equivalent dipole sources inside the brain. We have solved an inverse problem to estimate an equivalent dipole-layer distribution from the scalp electroencephalogram using spatio-temporal inverse filters. We estimated the position and moment of equivalent dipole sources from dipole layer distributions and separated each dipole layer distribution using in...

Background: Brain electrical activity is a spatio-temporally distributed process. Cortical imaging techniques have been developed to reconstruct cortical activity from the scalp electroencephalographic or magnetoencephalographic measurements. Several cortical imaging approaches, such as the epicortical potentials and a dipole layer accounting for the cortical activity, have been used to represe...

Dynamical causal modeling (DCM) of evoked responses is a new approach to making inferences about connectivity changes in hierarchical networks measured with electro- and magnetoencephalography (EEG and MEG). In a previous paper, we illustrated this concept using a lead field that was specified with infinite prior precision. With this prior, the spatial expression of each source area, in the sen...