Six hundred fifteen isolates of Streptococcus pyogenes were collected over a 6-year period from patients with pharyngitis in Korea. All isolates were characterized in terms of their antibiotic resistance, the phenotypes of erythromycin resistance, the frequencies of erm(B), erm(A), and mef(A) genes, and the emm genotype. The prevalent emm genotypes were emm12 and emm4. Moreover, the emm12 genot...

Sir, We read the recently published paper of Atkinson et al. with interest. The authors have misrepresented and misquoted our study by referencing primers we did not use or advocate [Table 1 and Table S1 (available as Supplementary data at JAC Online)]. The erm(A) and mef(A) primer sets Atkinson et al. reported to have produced false-positive PCR results were not used in our study nor described...

We have described recently the Ets family transcription factor, ERM/ETV5, specifically up-regulated in endometrioid endometrial carcinoma (EEC) and associated with myometrial infiltration. Ets family members have been correlated to tumor progression by up-regulating the expression of matrix-degrading proteases. In the present study, we investigated the possibility that in EEC, ERM/ETV5 may act ...

The major goal of periodontal therapy is periodontal regeneration including regeneration of alveolar bone, cementum and periodontal ligament fibres. Recapitulation of embryology shows the importance of Hertwig's epithelial root sheath (HERS), involved in cementogenesis and root formation. The remnants of these cells are found in normal periodontal ligament as the epithelial cell rests of Malass...

Aim: Antibiotic resistance studies about the Streptococcus have a great importance for treatment of especially child throat infections in terms public health and rational antibiotic use. For this purpose, we aimed to identify macrolide genes mef(E) erm(B). Material Method: The culture samples taken from 51 children presenting hospital with complaint sore were evaluated laboratory, S. pyogenes w...

The rate and pattern of neurogenesis in the developing vertebrate nervous system is controlled by a complex interplay of intercellular signalling pathways and transcriptional control mechanisms. In the zebrafish hindbrain, Fgf20a promotes transcription of the gene encoding the ETS-domain transcription factor Erm in the non-neurogenic centres of rhombomeres. Here, we demonstrate that the epigene...

Thirty-five of 40 clinical isolates of enterococci and streptococci cross-resistant to erythromycin and lincomycin and harbouring erm genes were inducibly resistant to these drugs, suggesting that ribosomal methylation is predominantly inducibly expressed in these bacterial genera. Regulatory regions located upstream of the erm genes of four inducible and three constitutive strains were amplifi...

PURPOSE The aim of the present study was to assess the expression of miRNAs in the Vitreous Humor (VH) of patients with Macular Hole (MH) and Epiretinal Membrane (ERM) compared to a control group. METHODS In this prospective, comparative study, 2-ml of VH was extracted from the core of the vitreous chamber in consecutive patients who underwent standard vitrectomy for ERM and MH. RNA was extra...

Article History: Received: Apr 20, 2009 Revised: May 6, 2009 Accepted: Jun 12, 2009 methicillin resistance has increased. The efficacy of macrolide antibiotics in the treatment of infections caused by multi-resistant staphylococci makes them the most often prescribed drugs in clinical medicine. How ever, the expanded use of these antibiotics has been accompanied by increased resistance rates am...

OBJECTIVES Macrolide, lincosamide and streptogramin type B (MLS(B)) resistance was determined in Staphylococcus aureus clinical isolates from two University Hospitals. METHODS Antibiotic resistance was investigated by double disc diffusion and MIC determination. Resistance determinants were detected by PCR and DNA hybridization, while clonal types were identified by pulsed-field gel electroph...