Erythroderma may be secondary to a cutaneous T-cell lymphoma (CTCL) and various other erythrodermic inflammatory dermatoses (EID), and their histopathologic distinction is often difficult. The aim of this study was to determine if morphological parameters, namely: the presence of b-catenin, and JunB (previously shown to be expressed by CTCL cells), the epidermal CD8:CD3 ratio, and CD30 expressi...

A 20-year-old girl presented with a one-week history of fever and chills, malaise, generalized erythema (including the face, trunk, back and extremities), edema (initially the face and then lower limbs) and hoarseness (Figure 1). Physical examination revealed low-grade fever, jaundice, lymphadenopathy (posterior cervical, submandibular, <1 cm, no axillary, no inguinal). Dermatological exa...

Erythroderma is a potentially fatal dermatologic emergency that is often mistaken for infection. Indeed, the fact that it is difficult to diagnosis is the main contributor to its significant mortality rate, as treatment is readily available. We present a case of a 36-year-old man who was incorrectly diagnosed and treated for 2 months. We review the etiologies, initial work-up and management of ...

BACKGROUND AND OBJECTIVES The exact immunophenotypic criteria for the identification of Sézary cells in the blood are still poorly defined. DESIGN AND METHODS We analyzed the immunophenotype and DNA cell content of blood T cells in a series of 18 consecutive cases of Sézary's syndrome (SS), 21 normal individuals and 10 patients with reactive erythroderma, and correlated them with molecular an...

An increasing number of new drugs have been incriminated in the recent past. 2–9 Its clinical pattern is fascinating and has been the subject of detailed studies. 4,8,10–16 Its changing scenario in various age groups, 17–19 its presentation postoperatively, 20–22 and its occurrence in human immunodeficiency virus (HIV)-positive individuals 23–25 are vivid indicators. Several factors may be resp...