OBJECTIVE To assess the safety and efficacy of once-daily (QD) adjunctive eslicarbazepine acetate (ESL). METHODS This post-hoc pooled analysis of three randomized, placebo-controlled trials (2093-301, -302, -304) involved adults with refractory partial-onset seizures (POS) receiving 1-3 antiepileptic drugs (AEDs). All studies included 8-week baseline, 2-week titration, and 12-week maintenance...

Different writing systems in the world select different units of spoken language for mapping. Do these writing system differences influence how first language (L1) literacy experiences affect cognitive processes in learning to read a second language (L2)? Two groups of college students who were learning to read English as a second language (ESL) were examined for their relative reliance on phon...

In this paper we introduce Epistemic Strategy Logic (ESL), an extension of Strategy Logic with modal operators for individual knowledge. This enhanced framework allows us to represent explicitly and to reason about the knowledge agents have of their own and other agents’ strategies. We provide a semantics to ESL in terms of epistemic concurrent game models, and consider the corresponding model ...

BACKGROUND Late vascular responses after implantation of drug-eluting stents may play a key role in steadily increasing occurrence of very late stent thrombosis have not yet been fully investigated in human beings. METHODS AND RESULTS Serial optical coherence tomography observations at 2 and 4 years were collected for 17 patients treated with 21 sirolimus-eluting stents. Corresponding 376 cro...

PURPOSE To compare the bioavailability (BA) and pharmacokinetic (PK) properties and to demonstrate the bioequivalence (BE) between two active product ingredient (API) sources of eslicarbazepine acetate (ESL) in healthy volunteers. DESIGN, SUBJECTS AND METHODS Forty healthy male and female subjects aged 18-40 years were randomized to treatment with 400 or 800 mg ESL marketed (MF) formulation [...

SystemC has grown its user community for system level design space exploration because of its capability of modeling at abstraction levels of RTL and above. However, designers using SystemC must explicitly manage the concurrency, which often contributes to design difficulties. To counter this difficulty, we extended SystemC with Bluespec-SystemC that we call BS-ESL for electronic system level l...

PURPOSE To evaluate the safety of eslicarbazepine acetate (ESL) in new onset elderly poststroke seizure patients, especially with respect to hyponatremia. METHOD In a two year, single center open labeled observational study of ESL in patients with imaging proven stroke with new onset post stroke seizure were included. ESL was titrated between 400mg and 1200 mg once daily during 1 month observ...

A two-dimensional model is used to simulate the motion and deformation of a single mammalian red blood cell (RBC) flowing close to the wall of a microvessel, taking into account the effects of a porous endothelial surface layer (ESL) lining the vessel wall. Migration of RBCs away from the wall leads to the formation of a cell-depleted layer near the wall, which has a large effect on the resista...

OBJECTIVE Functional studies show that disruption of endothelial surface layer (ESL) is accompanied by enhanced sensitivity of the vasculature towards atherogenic stimuli. However, relevance of ESL disruption as causal mechanism for vascular dysfunction remains to be demonstrated. We examined if loss of ESL through enzymatic degradation would affect vascular barrier properties in an atherogenic...

In this paper we put forward Epistemic Strategy Logic (ESL), a logic of knowledge and strategies in contexts of imperfect information. ESL extends Strategy Logic by adding modal operators for individual and collective knowledge. This enhanced framework allows us to represent explicitly and to reason about the knowledge agents have of their own and other agents’ strategies. We provide a semantic...