Background: Gastro-Esophageal reflux disease (GERD) is a very common problem in gastrointestinal clinical setting. Still, the best treatment for it remains debatable as there are many new drugs that have evolved its addition to dietary modification.Objective: To compare efficacy of Dexlansoprazole (modified-release 60 mg) and esomeprazole (40 resolution symptoms GERD.Material Methods: This rand...

BACKGROUND Use of proton-pump inhibitors in the management of peptic ulcer bleeding is controversial because discrepant results have been reported in different ethnic groups. OBJECTIVE To determine whether intravenous esomeprazole prevents recurrent peptic ulcer bleeding better than placebo in a multiethnic patient sample. DESIGN Randomized trial conducted between October 2005 and December ...

Esomeprazole, the S-isomer of omeprazole was developed with the aim of improving the pharmacokinetic and pharmacodynamic profiles of racemic omeprazole [1]. It suppresses the secretion of hydrochloric acid from gastric parietal cells via inhibition of the H+/K+ adenosine triphosphatase enzyme like other proton pump inhibitors [2]. Among all proton pump inhibitors available, esomeprazole is the ...

BACKGROUND The Arkansas State Employee Benefits Division (EBD) is a self-insured program comprising public school and other state employees, their spouses, and dependents. Previous research published in JMCP (2006) showed drug cost savings of $2.20 per member per month (PMPM; 37.6%) or annualized savings of $3.4 million associated with a benefit design change and coverage of the proton pump inh...

Proton pump inhibitors (PPIs) are widely prescribed drugs in daily practice. Allergic reactions, even small number of anaphylactic reactions to PPIs have been reported. Omeprazole, lansoprazole, pantoprazole, rapeprazol and esomeprazole are classified in the same group. Despite the similarity of biochemical structures among these drugs, presence of cross-reactivity between PPIs is controversial...

A simple, specific and sensitive reverse phase high performance liquid chromatographic method was developed and validated for simultaneous determination of esomeprazole and domperidone from pharmaceutical dosage forms. The method uses ODS C18 column and isocratic elution. The mobile phase composed of methanol: phosphate buffer (pH 4.0) in the ratio of 65:35 v/v was used at a flow rate of 1.0 ml...

PURPOSE The optimal delivery medium for esomeprazole magnesium enteric-coated pellets dispersed in various concentrations of Ora-Plus suspension through commonly used nasogastric and gastrostomy tubes using a previously used standardized in vitro protocol was studied. METHODS The study was conducted in two phases. In phase A, 60 size 14 French nasogastric tubes were used to compare esomeprazo...

BACKGROUND Inadequate response to proton pump inhibitor (PPI) therapy in patients with gastroesophageal reflux disease (GERD) is reported in up to 40%. Patients with non erosive reflux disease (NERD) have lower response rates compared to patients with erosive reflux disease (ERD); pH metry contributes to GERD diagnosis and is critical for proper diagnosis of NERD. Aim of the study was to assess...

Objective: The purpose of this study was to examine the clinical efficacy, tolerability, and safety Esomeprazole 20 mg + sustained release (SR) Domperidone 30mg delivered once daily in adult patients for symptomatic alleviation dyspepsia associated with GERD. Study Design: Prospective Place Duration: PIMS Hospital Islamabad. Dec 2021- May 2022 Methods: Total 97 both genders had GERD were presen...

OBJECTIVE Case reports showing that proton-pump inhibitors (PPIs), omeprazole and esomeprazole, can cause hypomagnesaemia have been accumulating since 2006. In this study, the reports submitted to the Adverse Event Reporting System (AERS) of the US Food and Drug Administration (FDA) were evaluated to assess omeprazole and esomeprazole in terms of susceptibility to hypomagnesaemia. METHODS Aft...