Introduction: The relationship between Ηelicobacter pylori (hp) gastritis, the most common infection worldwide and Gastroesophageal Reflux Disease (GERD), a major health problem in Western Countries, remains controversial. AIM: To investigate the association between hp infection and GERD and the impact of hp eradication on esophageal acid exposure and esophageal motility in hp-positive patients...

AIM To investigate the potential role of poly(ADP-ribose) polymerase 1 (PARP1) in the development of Barrett's esophagus (BE). METHODS A BE mouse model was established to examine the esophageal morphological changes and molecular changes. Microarray analysis was performed to compare the gene expression profiles between BE patients and healthy controls. qPCR was used to examine the PARP1 expre...

BACKGROUND/AIMS The necessity of manometric evaluation before fundoplication in patients with gastroesophageal reflux disease is still a matter of debate. However, misdiagnosis can be responsible for postoperative problems. We aimed to evaluate the necessities of manometry and pH-metry before fundoplication in order to prevent possible complications after surgery. METHODS Between 1997 and 200...

Distension of the esophagus can cause heartburn and chest pain; however, none of the available techniques to study the esophagus measure esophageal distension. We evaluated the technique of high-frequency intraluminal ultrasound probe (HFIUS) to measure the esophageal cross-sectional area (CSA) during gastroesophageal reflux (GER). The following methods were used: 1) the CSA of agarose gel tube...

approximately 20% of caustic ingestions result in some degree of esophageal injury. alkaline materials are the most frequent corrosive materials ingested.     the physical form and ph of ingested materials play a critical role in the site and type of gastrointestinal injury (ph > 12 or ph < 1.5, crystalline drain cleaners). unlike alkaline solutions, strong acids are bitter, burn on contact and...

This study was conducted to assess esophageal function and pulmonary resistance changes with esophageal acidification in patients with COPD. Twelve patients with COPD and a mean age of 55.6 years were studied. Each patient underwent standard esophageal manometry, 24-h ambulatory pH testing, esophageal acid clearance evaluation during sleep, and an assessment of pulmonary resistance with and wit...

To promote the appropriate use of new or emerging technologies, the American Society for Gastrointestinal Endoscopy Technology Committee has developed a series of status evaluation papers. This process presents relevant information about these technologies to practicing physicians for the education and the care of their patients. In many cases, data from randomized controlled trials are lacking...

The incidence of gastroesophageal reflux disease (GERD) is increasing and if left untreated can lead to significant patient morbidity and even death. The disease results from the abnormal reflux of gastric contents into the distal esophagus causing symptoms in most and subsequent mucosal damage in some. Several investigations can be used to confirm the diagnosis, but most are dependent on the p...

BACKGROUND/AIMS Approximately one-third of non-erosive reflux disease (NERD) patients are refractory to proton pump inhibitors (PPI) and face a therapeutic challenge. Therefore, it is important to differentiate between pathological and non-pathological reflux utilizing multichannel intraluminal impedance-pH (MII-pH) to analyze symptom-reflux association and diagnose true NERD versus hyper-sensi...

BACKGROUND Non cardiac chest pain can be caused by esophageal problems such as gastroesophageal reflux or smooth muscle motor disorders. AIM To perform esophageal manometry in patients with non cardiac chest pain. MATERIAL AND METHODS One hundred patients with chest pain in whom coronary problems were discarded, were studied. A computerized esophageal manometry was performed in all and 24 h...