Contemporary combined therapies that include the use of all-trans retinoic acid (ATRA) and arsenic compounds have reduced relapse rates from ~50 to <10% in acute promyelocytic leukemia (APL) patients, however relapse treatment remains controversial. Treatment outcomes in relapsed patients with APL previously treated with combined ATRA + arsenic compound therapy were investigated. A retrospectiv...

Long time uptake arsenic will cause cancers and blackfoot disease. There are still several million people suffering from drinking arsenic ontaminated water. This work studied the performance of coupled chitosan/UF for arsenic removal and the influence of dissolved organic matter n arsenic removal with UF operation. Humic acid representing dissolved organic matter was fractionated into five grou...

objectives the overall goal of this study was to carry out a set of comparative analyses of arsr gene in plasmid r773 and bacterial chromosome from escherichia coli bl-21(de3). methods pdb and ncbi databases and chimera, mega4, clc main workbench software and 3d-jigsaw and embl-ebi servers were applied to perform this study. by using these software and servers, multiple analyses including deter...

Arsenic is a naturally occurring element, present in soil, ground water and plants. Regions with high geological occurrence of inorganic arsenic have been identified in particular in Asia and other non-European countries. In Europe, environmental arsenic levels are rather low, with the exception of distinct geological or industrial areas. Arsenic is a metalloid, displaying different valences (-...

We have performed two-stage transformation assay using BALB/c 3T3 cells to determine initiating and promoting activities of disodium arsenate, sodium arsenite, monomethylarsonic acid (MMAA) and dimethylarsinic acid (DMAA). Treatment with these arsenic compounds at the initiating stage induced significant numbers of transformed foci when cells were post-treated with 12-O-tetradecanoylphorbol-13-...

First void urine samples were collected from copper smelter workers exposed to inorganic arsenic and from unexposed controls. Arsenic compounds (As (III), As (V), methylarsonic acid and dimethylarsinic acid) in these samples were analyzed by selective volatilization as arsines with determination of arsenic by plasma excitation emission spectrometry. On the day preceding the urine sample collect...

Arsenic compounds are classified as toxicants and human carcinogens. Environmental exposure to arsenic imposes a big health issue worldwide. Arsenic elicits its toxic efforts through many mechanisms, including generation of reactive oxygen species (ROS). Nrf2 is the primary transcription factor that controls expression of a main cellular antioxidant response, which is required for neutralizing ...

Investigations have been carried out by us in the Biochemical Laboratory of the Cardiff City Mental Hospital during 1938, 1939 and early 1940 on the effects of organic trivalent and pentavalent arsenic compounds on proteins and enzymes. The work was primarily undertaken to elucidate the biochemical basis of the trypanocidal and anti-spirochaetal action of a variety of organic arsenic compounds ...

Epidemiological studies have indicated that exposure of humans to inorganic arsenic in drinking water is associated with the occurrence of bladder cancer. The mechanisms by which arsenic induces this malignancy are still uncertain; however, arsenic metabolites are suspected to play a pivotal role. The aim of the present study was the investigation of uptake capabilities of human urothelial cell...