Introduction. Nephrotoxicity is one the side effect of cisplatin therapy and erythropoietin has been candidate as a nephroprotectant agent. However, its nephroprotective effect when it is accompained with estrogen has not been studied in female. Methods. 27 ovariectomized female Wistar rats divided into five groups. Groups 1 & 2 received estradiol valerate (0.5 mg/kg/week) for four weeks, and s...

Background: In recent years, a combination of hormones and agents in assisted reproductive technology (ART) cycles as a means of stimulating the ovary and developing more follicles. With respect to the positive effects of Estradiol Valerate on reproductive tissues and the impact on native genes of the egg that transferred to the embryo after fertilization, it seems that this agent can also effe...

Detection of estrogenic disrupting compounds (EDCs) in drinking waters around China has led to rising concerns about health risks associated with these compounds. There is, however, a paucity of studies on the occurrence and identification of the main compounds responsible for this pollution in the source waters. To fill this void, we screened estrogenic activities of 23 source water samples fr...

objective: : polycystic ovary syndrome (pcos) is one of the most common hormonal disorders that can lead to irregular menstrual cycles and hyperandrogenism. reduced levels of progesterone and increased estrogen in these women can perpetually stimulate the endometrial tissue of the uterus. in this study, the effect of pcos induction was studied using estradiol valerate. materials and methods: ad...

Background: Therapies available for thin endometrium are limited and mostly performed experimentally which most of these treatments have a similar function increase blood flow to the endometrium, causing it thicken develop. The aim study was compare effect estradiol valerate in combination with sildenafil on endometrial thickness infertile women before intrauterine insemination. Methods: In thi...

INTRODUCTION The role of ovarian hormones and nitric oxide in learning and memory has been widely investigated. OBJECTIVE The present study was carried out to evaluate the effect of the nitric oxide synthase (NOS) inhibitor, N (G)-nitro-L-arginine methyl ester (L-NAME), on the ability of estradiol to improve learning in OVX rats using the Morris water maze. METHODS Forty rats were divided i...

The importance of estrogens in the dietary lipid alteration of R3230AC mammary carcinoma growth and insulin binding was studied. Animals were divided into three groups [intact, ovariectomized, and ovariectomized treated with estradiol valerate (EV)] and were fed diets containing either 0% fat (fat free), 0.5% corn oil (low fat), or 20% corn oil (high fat). An alteration of tumor burden between ...

In the age of broad medical options, women’s health has received sufficient attention. The different periods a woman’s life are characterised by specific physiological changes, based on age-related characteristics reproductive system. onset menopause can have negative impact in varying degrees. Clinicians clear understanding effects estrogen deficiency and therapeutic options for managing it wi...

OBJECTIVE In this study, the effects of estradiol valerate and raloxifenea selective estrogen receptor modulator; (SERM) on morphine induced sensitization were examined in mice memory, according to the step-down passive avoidance task. METHOD The mice received morphine or estradiol and raloxifene for three days alone or in combination with morphine. After a drug free period of 5 days, the sub...