An 88-year-old woman presented with hemiballism of abrupt onset that mainly affected her left leg. Brain computed tomography revealed a hemorrhage at the right subthalamic nucleus (Picture 1). An easy Z-score imaging system analysis of single photon emission computed tomography (SPECT) using Tc-ethyl cysteinate dimer revealed hyperperfusion at the right motor cortex corresponding to the leg and...

PURPOSE Several reports have suggested that multilingualism has a protective effect against semantic dementia. Here, we provide further evidence for this effect. CASE REPORTS FIRST The patient was a 75-year-old right-handed Taiwanese woman who had retired after working as a tailor. She was able to speak Taiwanese, Japanese and Mandarin Chinese fluently until 5 years ago. She gradually develop...

BACKGROUND AND PURPOSE It is unclear from recent clinical trials whether thrombolytic agents are capable of facilitating reperfusion and metabolic recovery over time or whether a beneficial effect is counteracted by an increase in the risk of brain hemorrhage. We studied the effect of thrombolytic treatment on metabolic recovery after reperfusion and clinical outcome. METHODS Patients were pr...

Background and Purpose—Extracorporeal rheopheresis is a safe method to optimize hemorheology. Our aim was to determine whether treatment with extracorporeal rheopheresis in patients with acute ischemic hemispheric stroke improves cerebral perfusion as assessed with serial Tc–ethyl-cysteinate-dimer single-photon emission CT (TcECD SPECT). We also investigated how clinical outcome is associated w...

OBJECTIVE Cerebral microbleeds (MBs) have been previously associated with cognitive dysfunction, including Alzheimer's disease. In the present study, we aimed to clarify the relationship between cerebral lobar MBs and the regional cerebral blood flow (CBF). METHODS We investigated the data obtained from 122 patients in our memory clinic who were examined by both MRI and (99m)Tc-ethyl cysteina...

Objective Chronic fatigue syndrome (CFS) is a complex disorder, with no consensus on therapeutic options. However, Waon therapy has been reported to be an effective treatment. The purpose of this study was to evaluate changes in the cerebral blood flow (CBF) before and after Waon therapy in CFS patients and to investigate the correlation between such changes and the therapeutic efficacy of Waon...

Increases in regional cerebral blood flow have been described in a variety of cerebral pathologic states, including stroke and seizure disorders. The usefulness of technetium-99m-labeled cysteinate dimer as a marker in the measurement of regional cerebral blood flow was tested in five cynomolgus monkeys. To expand the range of blood flow to beyond the normal limits, 40 mg/kg i.v. of the carboni...

Increases in regional cerebral blood flow have been described in a variety of cerebral pathologic states, including stroke and seizure disorders. The usefulness of technetium-99m-labeled cysteinate dimer as a marker in the measurement of regional cerebral blood flow was tested in five cynomolgus monkeys. To expand the range of blood flow to beyond the normal limits, 40 mg/kg i.v. of the carboni...

Ictal bradycardia, which is considered to be one of the causes of sudden unexplained death in epilepsy, is rare. A 10-year-old girl with focal cortical dysplasia in her right centroparietal region developed transient ictal bradycardia during cluster seizures. Brain magnetic resonance imaging demonstrated a high signal intensity lesion adjacent to the focal cortical dysplasia lesion. Ictal 99mTc...

J Nucl Med. Udalrich Buell, Michel C. De Roo and Robert A. Morgan Jean-Luc Moretti, Angelika Bischof-Delaloye, Thomas C. Hill, Pierre M. Rigo, Ronald L. Van Heertum, Peter J. Ell, B. Leonard Holman, Robert S. Hellman, Stanley J. Goldsmith, Ismael G. Mena, Jean Leveille, Paolo Gerundini Gherardi, Dimer in Normal Subjects and in Patients with Chronic Cerebral Infarction Biodistribution, Dosimetry...