The aim of the present study was to develop Exemestane loaded polymeric nanoparticles for improved oral bioavailability of Exemestane. Exemestane loaded nanoparticles were prepared by solvent displacement method with Eudragit RL 100 and Eudragit L 100 as polymers and Pluronic® F-68 as surfactant. The influence of various formulation factors (drug: polymer ratio and concentration of surfactant) ...

The present study aimed at the formulation of matrix tablets for colon-specific drug delivery (CSDD) system of indomethacin (IDM) by applying liquisolid (LS) technique. A CSDD system based on time-dependent polymethacrylates and enzyme degradable polysaccharides was established. Eudragit RL 100 (E-RL 100) was employed as time-dependent polymer, whereas bacterial degradable polysaccharides were ...

The aim of this study was to evaluate the suitability of Raman spectroscopy as a Process Analytical Technology (PAT) tool for the in-line determination of the active pharmaceutical ingredient (API) concentration and the polymer-drug solid state during a pharmaceutical hot-melt extrusion process. For in-line API quantification, different metoprolol tartrate (MPT)--Eudragit® RL PO mixtures, conta...

background microencapsulation is a useful method to prolong a drug release from dosage forms and to reduce its adverse effect (1) among various available methods. the microencapsulation of hydrophilic active ingredients requires the use of a polar dispersing phase such as a mineral oil. acetone/paraffin systems are conventionally used. objectives the current study aimed to investigate two diffe...

the objective of the present investigation was to design a sustained release floating microcapsules of theophylline using two polymers of different permeability characteristics; eudragit rl 100 (eu rl) and cellulose acetate butyrate (cab) using the oil-in-oil emulsion solvent evaporation method. polymers were used separately and in combination to prepare different microcapsules. the effect of d...

diclofenac sodium as ophthalmic dosage form is used in patients treatment of eye pain, swelling and redness recovering from cataract surgery but it faces the bioavailability limitation of eye drops due to effective protective mechanisms and corneal barrier functions in the eyes. therefore, this investigation was aimed to develop ocular film formulations to achieve controlled drug release. drug ...

the aim of the present study was to develop exemestane loaded polymeric nanoparticles for improved oral bioavailability of exemestane. exemestane loaded nanoparticles were prepared by solvent displacement method with eudragit rl 100 and eudragit l 100 as polymers and pluronic® f-68 as surfactant. the influence of various formulation factors (drug: polymer ratio and concentration of surfactant) ...

The objective of the present investigation was to design a sustained release floating microcapsules of theophylline using two polymers of different permeability characteristics; Eudragit RL 100 (Eu RL) and cellulose acetate butyrate (CAB) using the oil-in-oil emulsion solvent evaporation method. Polymers were used separately and in combination to prepare different microcapsules. The effect of d...

A multiparticulate system was developed using the coating pan method with nonpareil seed as the core material for the Theophylline. The drug loaded pellets were prepared by powder layering technique, sprinkling the drug on the nonpareil seeds using PVP K-30 in IPA as binder. The drug loaded pellets were coated by using polymers ethyl cellulose, EUDRAGITRS:RL (2:1) and EUDRAGIT® RS:RL (3:1). The...