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تعداد نتایج: 344413 فیلتر نتایج به سال:
OBJECTIVES Interleukin-6 (IL-6) is implicated in rheumatoid arthritis (RA) pathophysiology. Unlike IL-6 receptor inhibitors, sirukumab is a human monoclonal antibody that selectively binds to the IL-6 cytokine. The phase III, multicentre, randomised, double-blind, placebo-controlled, parallel-group SIRROUND-D study (ClinicalTrials.gov identifier NCT01604343) evaluated the efficacy and safety of...
background : gestational trophoblastic neoplasia (gtn) disease is excessive and inappropriate proliferation of trophoblast after termination of the pregnancy. many attempts have been made to improve follow-up procedures, but no studies have evaluated human chorionic gonadotrophin (hcg) as a post treatment indicator. thus we aimed to know β-hcg variability in post treatment pregnancies. method...
BACKGROUND This phase I dose-escalation study was designed to determine the maximum tolerated dose (MTD) and recommended dose of cetuximab administered on an every-second-week schedule to patients with metastatic colorectal cancer, on the basis of safety, pharmacokinetic and pharmacodynamic evaluation. PATIENTS AND METHODS The study comprised two parts: a 6-week cetuximab monotherapy dose-esc...
PURPOSE To determine week 52 efficacy and safety outcomes in eyes with macular edema after branch retinal vein occlusion (BRVO) treated with 2 mg intravitreal aflibercept injection (IAI) compared with grid laser. DESIGN VIBRANT was a double-masked, randomized, phase 3 trial. PARTICIPANTS Eyes randomized and treated in VIBRANT were followed to week 52. METHODS In the IAI group, eyes receiv...
OBJECTIVE To determine the optimal methotrexate dose in individual patients and to explore whether this optimal dose and the level of disease activity at that dose could be predicted. METHODS Data from CAMERA II trial comparing MTX and MTX with 10 mg of prednisone both in a tight control treatment strategy in early RA was used. For each patient a curve for disease activity over time was fitte...
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