Abstract Aim This case highlights the need for appropriate training when adopting new techniques, even relatively simple procedures. Method we report a rare complication of innovative COVID-19 nasopharyngeal swab which is skill many healthcare professionals and frequently performed with little or no training. Results We describe iatrogenic epistaxis after diagnostic was taken during pandemic. T...

Book review on Mlada Holá – Martin Holý (Hg.), Das Studentenkolleg der Böhmischen Nation Prager Universität. Edition Rechnungen aus den Jahren 1541–1611, Berlin Münster 2019, LIT Verlag, 438 s., 9 vyobr., 1 mapka a řada tabulek v úvodním textu; ISBN 978-3-643-14182-8.

The endothelins (ETs), potent vasoconstrictor peptides, have been implicated in the pathogenesis of various cardiovascular disorders. In the present study, we describe the novel, potent, orally active, selective ET(A) receptor antagonist ZD1611 [3-(4-[3-(3-methoxy-5-methylpyrazin-2-ylsulfamoyl)-2-pyridyl ]phenyl)- 2,2-dimethylpropanoic acid]. ZD1611 competitively inhibited (125)I-labeled ET-1 b...

1 Digital Communications Research Laboratory, National University of Cordoba (UNC) CONICET, Avenida Velez Sarsfield 1611, X5016GCA Cordoba, Argentina 2 Department of Communications and Networking, Helsinki University of Technology (TKK), P.O. Box 3000, FIN-02015 TKK, Finland 3 Department of Signal Processing and Acoustics, Helsinki University of Technology (TKK) Smart and Novel Radios (SMARAD) ...

traditional Chinese herbal medicine Chuanxiong and Awei but also contained in coffee beans and rice as well as a polyphenol-rich food supplement known to have strong antioxidant activity and different beneficial effects on human health. There have been many reports on the pharmacological actions of FA including hepato-protective effect, scavenging oxygen free radicals, inhibiting platelet aggre...

After identification and validation of targets in a drug development process, some independent lead compounds should be selected and optimized for their activities. Then, safety assessments and clinical trials decide whether the drug is proper to enter the market. Different stages of this process (and especially the identification of lead compounds) are extremely expensive and time-consuming. R...