PURPOSE The expression of heat shock protein 47 (HSP47) was observed histologically to investigate the spatial and chronological effects of excimer laser photoablation. HSP47 expression after radial keratotomy (RK) was also investigated and compared with the effects after excimer laser photoablation. METHOD Twenty-eight male rabbits were used. The rabbits were divided with two groups and trea...

OBJECTIVE To evaluate the effects of excimer laser in situ keratomileusis in correcting severe myopia and astigmatism after penetrating keratoplasty. METHODS Excimer laser in situ keratomileusis was performed on ten eyes of ten patients to correct high ametropia in cases having previously undergone penetrating keratoplasty. RESULTS After surgery, all grafts remained clear and no corneal gra...

Just when we thought photorefractive keratectomy (PRK) had achieved a level of safety and predictability in correcting refractive errors in our patients, new wounding healing information regarding apoptosis (programmed cell death) surfaces to show us that the way we remove the corneal epithelium matters a great deal in how the corneal stroma responds to our treatment.1 Excimer laser manufacture...

PURPOSE To evaluate long-term results of sequential customized therapeutic keratectomy (SCTK) in highly aberrated corneas with apical scars consequent to hyperopic excimer laser refractive surgery. METHODS Fifteen eyes of 12 patients treated with SCTK for a corneal apical scar after hyperopic excimer laser refractive surgery were retrospectively evaluated. SCTK is a sequence of custom therape...

BACKGROUND/AIMS The biochemical basis for the development of subepithelial opacity of the cornea after excimer laser keratectomy has yet to be fully defined. The aim of this study was to evaluate the alterations of glycosaminoglycans (GAGs) after excimer laser keratectomy. METHODS Rabbit corneas were harvested on days 5, 10, 20, and 30 after excimer laser photoablation. The amount of main dis...

AIM To evaluate the histological changes after transepithelial corneal crosslinking (CXL) using partial thickness excimer laser ablation or epithelial ethanol application in an experimental rabbit study. METHODS Right eyes of twenty-four rabbits were studied. Four eyes received total epithelial debridement (group I). Four eyes received partial thickness epithelial ablation with excimer laser ...

OBJECTIVES Coronary lumen changes during and after excimer laser-assisted balloon angioplasty were measured by quantitative coronary angiography, and the results were compared with the effects of balloon angioplasty alone. BACKGROUND Reduction of atherosclerotic tissue mass by laser ablation in the treatment of coronary artery disease may be more effective in enlarging the lumen than balloon ...

Excimer laser ablation of gold films deposited on a quartz crystal microbalance is investigated. The ablation rate is directly obtained from the frequency shift of the microbalance. The measured single-shot ablation rate is found to be at least two orders of magnitude higher than the numerical predictions based on a surface vaporization model. Surface morphologystudies indicate that hydrodynami...

BACKGROUND One human pathology specimen has been studied previously following the use of the excimer laser for the correction of astigmatism. We report histopathologic findings following linear corneal excisions with the excimer laser. METHODS A 193 nm excimer laser was used to create symmetrical, transverse excisions in a human eye to correct astigmatism. Three months later, a full-thickness...