Hydrogels provide effective alternatives for drug delivery when therapeutics cannot be applied directly to a wound, or if adverse effects are associated with systemic administration. However, vehicles need biocompatible and biodegradable exhibit sufficient mechanical strength withstand handling different physiological conditions, such as those encountered during topical administration of therap...

Platelet-derived growth factor (PDGF) is a potent activator for cells of mesenchymal origin. PDGF stimulates chemotaxis, proliferation, and new gene expression in monocytes-macrophages and fibroblasts in vitro, cell types considered essential for tissue repair. Therefore, we analyzed the influence of exogenously administered recombinant B chain homodimers of PDGF (PDGF-BB) on two experimental t...

BACKGROUND Low levels of laser or non-coherent light, termed low-level light therapy (LLLT) have been reported to accelerate some phases of wound healing, but its clinical use remains controversial. METHODS A full thickness dorsal excisional wound in mice was treated with a single exposure to light of various wavelengths and fluences 30 minutes after wounding. Wound areas were measured until ...

Objective-This study was conducted to evaluate the effect of co-administration of Aloe vera gel and cinnamon zeynalicum bark hydroethanolic extract on process of wound healing in diabetic mice model.Design- Experimental Study.Animals- Seventy-two male BALB/c mice.Procedures- A single full-thickness excisional wound was created on ba...

Four elderly patients with multiple comorbidities, polypharmacy, and social issues requested surgical management of sizeable, symptomatic skin cancers: basal cell carcinomas (BCC), squamous cell carcinoma (SCC), and melanoma. All patients desired closure methods that would avoid extensive reconstruction and minimize wound care responsibilities. In this retrospective case series, we investigated...

Objective - The objective of the present study was to assess effect of Propolis in combination with chitosan biofilm on excisional wounds. Design- Experimental Study.Animals- Male healthy Wistar rats.Procedures- Sixty-four rats were randomized into four groups of 16 rats each. Group I: Animals with wounds treated with 0.9% saline solution. Group II: Animals with wounds were dr...

Mechanical stress following surgery or injury can promote pathological wound healing and fibrosis, and lead to functional loss and esthetic problems. Splinted excisional wounds can be used as a model for inducing mechanical stress. The cytoprotective enzyme heme oxygenase-1 (HO-1) is thought to orchestrate the defense against inflammatory and oxidative insults that drive fibrosis. Here, we inve...