It has been shown that endogenous nitric oxide (NO), measured in exhaled air, is increased in asthmatic subjects and after allergen challenge in sensitized animals. NO is also a paracrine molecule with some, though weak, bronchodilator effects. However, whether the amount of endogenous NO that originates in the lungs can reflect the degree of bronchial tone and airways calibre in asthmatic subj...

STUDY OBJECTIVES The aim of this study was to explore the relationship between quality of life and measures of asthma, such as lung function, reversibility to bronchodilation, exhaled nitric oxide (NO), and bronchial responsiveness to direct and indirect stimulus in patients with mild asthma in a primary care setting. PATIENTS AND MEASUREMENTS Seventy-seven asthmatic patients not treated with...

Nuclear magnetic resonance (NMR)-based metabolomic analysis of exhaled breath condensate (EBC) is a noninvasive approach that has been used to study diseases of the respiratory system [1, 2]. In a previous study, we questioned the accuracy of NMR-based EBC analysis, demonstrating that the cleaning protocols for reusable condenser parts produce a confounding metabolite fingerprint largely unrela...

Fractional exhaled nitric oxide concentration (FENO) depends on exhalation flow; however, children often are unable to perform controlled flow procedures. Therefore, a device was developed for off-line FENO sampling, with dynamic flow restriction (DFR). The authors compared off-line with on-line FENO, assessed feasibility, and obtained normal values for FENO in children aged 4-8 yrs. Subjects i...

Measurement of nitric oxide levels in exhaled air is commonly performed using a chemiluminescence detector. However, water vapour and carbon dioxide affect the chemiluminescence process. The influence of these gases at the concentrations present in exhaled air, has not yet been studied. For this in vitro study, mixtures of 50, 100 and 200 parts per billion (ppb) NO in air were prepared and fed ...

The effect of carbon dioxide (CO2) exhaled by wind instrument players on the resulting pitch is investigated. A theoretical-numerical approach is applied to determine the dependence of sound velocity on the percentage of CO2 contained in the air. Realistic performance data were obtained from experiments in which a professional musician played a clarinet and an oboe, while the CO2 content of exh...

A sensitive and rapid method for the determination of toluene in exhaled air is described. We have developed a device for direct breath sampling consisting of a sampler inserted into an empty 58 mL glass vial closed by a Teflon rubber septum. The sorbent cartridge functions as a diffusive sampler and employs a Tenax resin (300 mg, 35/50 mesh) to trap volatile organic compounds from the exhaled ...

Introduction Nitric Oxide Source of NO in exhaled air Measurement Asthma COPD Cystic fibrosis Bronchiectasis Primary ciliary dyskinesia Rhinitis Interstitial lung diseases Pulmonary hypertension Occupational diseases Infections Chronic cough Lung cancer Lung transplant rejection Adult respiratory distress syndrome Diffuse Panbronchiolitis Carbon Monoxide Source of exhaled CO Measurement Asthma ...

Endogenous production of nitric oxide can be detected and monitored in exhaled air of men and animals. The main objective of this review was to discuss if nitric oxide in exhaled breath condensate is a useful tool when investigating respiratory dysfunctions in intensive care units. Specialized literature reveals an increasing interest in the use of exhaled breath condensate as a non-invasive me...

The relationship of exhaled ethane and n-pentane to exhaled NO, carbonylated proteins, and indoor/outdoor atmospheric pollutants were examined in order to evaluate ethane and n-pentane as potential markers of airway inflammation and/or oxidative stress. Exhaled NO and carbonylated proteins were found to have no significant associations with either ethane (p = 0.96 and p = 0.81, respectively) or...