Duchenne muscular dystrophy (DMD), the most common muscle degenerative disease, is an X-linked genetic disorder caused by loss or reduction of dystrophin protein, resulting in progressive wasting, and involving skeletal, cardiac, respiratory muscles. There currently no cure for DMD, anti-inflammatory steroid conventional treatment to delay disease progression. Recently, several therapeutic appr...

background: gastrointestinal stromal tumor (gist) is the most common mesenchymal neoplasm of the gastrointestinal tract. they are believed to originate from the interstitial cells of cajal. most of these tumors contain activating mutations in the kit receptor tyrosine kinase. this is the first study in iran to evaluate gists at the molecular level. methods: in the present study, during 5 years ...

Polymorphisms in 5’-flanking region of prolactin (PRL), exon 2 and exon 5 of prolactin receptor (PRLR) genesand its association with growth and egg traits were examined in breeder hens of Mazandaran native fowlsbreeding station. A single nucleotide polymorphism at site C-2402T and a 24 bp nucleotide sequence insertionat situation -382 in 5’-flanking regions of PRL gene were id...

Background: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. They are believed to originate from the interstitial cells of Cajal. Most of these tumors contain activating mutations in the KIT receptor tyrosine kinase. This is the first study in Iran to evaluate GISTs at the molecular level.Methods: In the present study, during 5 years (...

Background: This study aimed to assess the frequency determination of c.1115_1118delTTGG and c.3788_3790delTCT Fanconi's anemia A gene (FANCA) gene mutation in the North of Khyber Pakhtunkhwa (KPK) Pakistan Fanconi’s Anemia Population. Materials and Methods: A cross-sectional study was conducted at Khyber Medical University, Peshawar, Pakistan. For the Exon 13 mutation c.1115_1118delTTGG, the ...

three species of l. tropica, l. major and l. infantum are known as main causal agents of leishmaniasis have been reported in iran. since cutaneous leishmaniasis (cl) is endemic in north east of iran, in the present work, 50 leishmania positive isolates from human cases in mashhad (center of razavi province, north east of iran), were genotyped by means of polymerase chain reaction-restriction fr...

Background: DNA polymerase β (pol β) is a key enzyme of base excision repair pathway. It is a 1-kb gene consisting of 14 exons. Its catalytic part lies between exon 8 and exon 14. Exon 12 has a role in deoxyribonucleotide triphosphate selection for nucleotide transferase activity. Methods: Genomic DNA was isolated from ovarian carcinoma samples. Single strand conformation polymorphism...