Surrogate assisted evolutionary algorithms (EA) are rapidly gaining popularity where applications of EA in complex real world problem domains are concerned. Although EAs are powerful global optimizers, finding optimal solution to complex high dimensional, multimodal problems often require very expensive fitness function evaluations. Needless to say, this could brand any population-based iterati...

We present an arc-consistency algorithm NAC4 to account for some types of non-binary constraints. It di ers from the generalized algorithm GAC4 [ Mohr and Masini, 1988 ] as the constraints need not be modeled as explicit relations but can be retained as implicit n-ary relations. The advantage of this algorithm over GAC4 is pronounced when the checking of constraints is expensive. By an ordering...

Immunologists/allergists are a physician group that is familiar with caring for patients with rare diseases. Conditions that come under the umbrella of our specialty include various primary immunodeficiency diseases, mast cell disorders, various autoinflammatory diseases and diseases of the complement cascade including Hereditary Angioedema (HAE). A rare or orphan disease is defined by the Euro...