Because of its large nucleus, the Xenopus laevis oocyte offers an excellent system to study nucleocytoplasmic transport. This system, in combination with electron microscopy, has provided much of our insight into the mechanisms of nuclear import and export. In a typical experiment, the nuclear transport substrate is first labeled with colloidal gold, and the resulting complex is injected into t...

The RanGTP-binding nuclear transport receptors transportin1 (TRN1) and transportin2 (TRN2) are highly similar in sequence but are reported to function in nuclear import and export, respectively. Here we show that TRN2 possesses properties of a nuclear import receptor. TRN1/2 both interacted with a similar set of RNA-binding proteins in a RanGTP-sensitive manner. TRN2 bound RanGTP with high affi...

in this article, real exchange rate behavior and its effects on macroeconomic variables are studied by explaining two models; impulse function and forecasting predicted error decomposition. studies show that high artificial currency value has caused domestic and foreign accounts equilibrium disturbance and foreign income decrease due to the slackening of commercial and agricultural activities, ...

the effect of symmetric (non-symmetric) foreign exchange rate shocks on iranian agricultural import and exports was explored throughout the current research.. time series of 1973-2007 along with hodrick and prescott filter method were employed. the results as obtained through vector error correction and johnson model indicated that positive (negative) shocks introduce positive (negative) effect...

BACKGROUND Nuclear protein import and export are mediated by receptor proteins that recognize nuclear localization sequences (NLSs) or nuclear export sequences (NESs) and target the NLS-bearing or NES-bearing protein to the nuclear pore complex (NPC). Temperature-dependent translocation of the receptor-cargo complex in both directions through the NPC requires the GTPase Ran, and it has been pro...

Iran`s pharmaceutical products market as one of the major markets of the country has been faced with fluctuations over time. Suitable market selection is necessary for stability of pharmaceutical exports. Study of the global market structure of this product leads to policy makers in development, production, and trade of pharmaceuticals and finally increases country’s share of the world pharmace...

Countries have long used import tari↵s as an instrument to stimulate or protect downstream industries; however, in the GATT/WTO era, tari↵s have fallen greatly worldwide. Has the WTO succeeded in limiting the prevalence of this class of industrial policy, or are governments still attempting to move downstream via other policy instruments? For countries with large raw materials endowments, one a...

We have identified a temperature-sensitive mutant of Saccharomyces cerevisiae (npl3) that accumulates polyadenylated RNA in the nucleus at 37 degrees C, as judged by in situ hybridization. The strong nuclear signal is not simply due to increased cytoplasmic turnover of mRNA, as reincubation at 37 degrees C with an RNA polymerase inhibitor shows no diminution in the in situ signal. Over several ...

Foreign trade expansion plays an important role in economic growth and development. Since Iran’s single-product economy is facing tight sanctions, among trading partners, Turkey benefits from special place, and political independence in international relations because of its large population, rising per capita income, high economic growth rate, geographical and cultural proximity to Iran. Many ...