Export and the readiness to export constitute the first step of international marketing, which are affected by both internal and external factors of firms. One of the most important internal  factors is the presence of skilled personnel. The purpose of this study was to define the relationship between staff qualification and encouragment with the readiness level of Iranian pharmacuetical firms ...

In poignant remembrance of the last Christmas in the Confederate White House, Varina Davis, First Lady of the Confederacy, reflected upon that special event in an extended article for the New York Sunday World, some thirty-two years after the Confederacy’s final Christmas. Davis recounted the event fondly and praised the transformation of her female peers into perfect models of Confederate endu...

This paper evaluates transformative policy innovations with respect to security and taxation in the three main Colombian cities: Bogotá, Medellín, and Cali. In the first two, such policies were associated with huge success. Elsewhere we (Gutiérrez et al. 2009) have tagged these transformation processes as ‘urban/metropolitan miracles’. The term comes from the fact that both common citizens and ...

Different RNA species are rigorously discriminated and exported by distinct export factors, but this discrimination mechanism remains largely unknown. We previously showed, by RNA microinjection experiments, that intronless mRNAs are discriminated from U snRNAs based on their difference in RNA length. However, it was unclear how they are discriminated in the natural situation in which their nas...

The yeast Sac3:Cdc31:Sus1:Thp1 (TREX-2) complex facilitates the repositioning and association of actively transcribing genes with nuclear pores (NPCs)-"gene gating"-that is central to integrating transcription, processing, and mRNA nuclear export. We present here the crystal structure of Sus1 and Cdc31 bound to a central region of Sac3 (the CID domain) that is crucial for its function. Sac3(CID...

The American Board of Pathology (ABP) has recently approved a physician-scientist research pathway (PSRP) for pathologists in training. This new pathway was specifically created to increase the recruitment of new physician-scientists to our specialty. Other specialties, such as internal medicine, pediatrics, radiology/radiation oncology, and dermatology, have formally Board approved research tr...

Export of mRNA from the nucleus is a central process in eukaryotic gene expression that has been implicated in several human diseases. Much of our understanding of how an mRNA is transported to the cytoplasm is derived from studies using yeast and fly models. We present here different mechanisms by which aberrant nuclear retention of mRNA can cause human disease. Emerging evidence that implicat...

In eukaryotic cells, the nuclear membrane creates a barrier between the nucleus and the cytoplasm. Whereas RNA synthesis occurs in the nucleus, they mostly function in the cytoplasm; thus export of RNA molecules from the nucleus to the cytoplasm is indispensable for normal function of the cells. The molecular mechanisms involved in each kind of cellular RNA export is gradually understood. The f...

a diversification of the country’s export structure through the concerted development of its export-oriented manufacturing capacity could offer a viable alternative, as also stipulated in the country’s second socioeconomic and cultural development plan, by increasing the resilience of its economy against external shocks, supporting employment creation and technological innovation, and adding do...

raisin is the second major export item in iranian agricultural section after pistachio. in this study, effects of exchange rate fluctuations were investigated on quantity and price of exported raisin. therefore, data of 1970 to 2008 were reviewed by time series analysis and estimated by auto-regressive distributed lag model (ardl). results show the absence of a long-term relationship between ex...