نتایج جستجو برای: extracellular matrix ecm

تعداد نتایج: 453411  

Journal: :American journal of physiology. Cell physiology 2010
Feng Shi Jennifer Harman Keigi Fujiwara Jane Sottile

Extracellular matrix (ECM) remodeling occurs during normal homeostasis and also plays an important role during development, tissue repair, and in various disease processes. ECM remodeling involves changes in the synthesis, deposition, and degradation of ECM molecules. ECM molecules can be degraded extracellularly, as well as intracellularly following endocytosis. Our data show that the ECM prot...

Journal: :acta medica iranica 0
fattah sotoodehnejadnematalahi department of regenerative biomedicine at cell science research center, royan institute for stem cell biology and technology, acecr, tehran, iran. bernard burke department of infection, immunity and inflammation, university of leicester, leicester, le1 9hn, uk.

one of the main members of the large aggregating proteoglycans (pgs) family is versican which is able to bind to hyaluronate. versican is a chondroitin sulfate proteoglycan and is a key ingredient of the extracellular matrix.  due to its widespread expression in the body, versican is involved in cell adhesion, proliferation and migration. induced expression of versican is often observed in tiss...

Journal: :Histology and histopathology 1996
M Slater

The extracellular matrix (ECM) is a dynamic assemblage of interacting molecules that reorganise and regulate cell functions in response to endogenous and exogenous stimulii. Matrix components may affect cell behaviour directly or indirectly through growth factor sequestration and transmembrane signalling, by controlling the speed of various molecules through the ECM, and the access of growth fa...

Journal: :gene, cell and tissue 0
tayebeh dahmardeh department of biology, faculty of sciences, ferdowsi university of mashhad, mashhad, ir iran nasser mahdavi shahri department of biology, faculty of sciences, ferdowsi university of mashhad, mashhad, ir iran; stem cell biotechnology research group, institute of biotechnology, ferdowsi university of mashhad, mashhad, ir iran; department of biology, faculty of sciences, ferdowsi university of mashhad, mashhad, ir iran maryam m. matin department of biology, faculty of sciences, ferdowsi university of mashhad, mashhad, ir iran; cell and molecular biotechnology research group, institute of biotechnology, ferdowsi university of mashhad, mashhad, ir iran; stem cell and regenerative medicine research group, iranian academic center for education, culture and research group, khorasan razavi branch, mashhad, ir iran morteza behnam rassouli department of biology, faculty of sciences, ferdowsi university of mashhad, mashhad, ir iran roya lari department of biology, faculty of sciences, ferdowsi university of mashhad, mashhad, ir iran

results migration of cells started on the fifth day. as a result of this migration, most cells were located on the surface of the scaffold and formed epiderm-like structure and some penetrated into the scaffold. by day 25, cells which had penetrated into the scaffold had various destinies such as becoming elongated spindle-shaped cells and creating blood vessel-like structures. conclusions adm ...

Journal: :Development 2021

ABSTRACT The developing heart is formed of two tissue layers separated by an extracellular matrix (ECM) that provides chemical and physical signals to cardiac cells. While deposition specific ECM components creates diversity, the also dynamic, with modification degradation playing important roles in maturation function. In this Review, we discuss spatiotemporal changes composition during develo...

Journal: :thrita 0
soraiya ebrahimpour koujan students research committee, department of biochemistry and diet therapy, faculty of nutrition, tabriz university of medical sciences, tabriz, ir iran bahram pourghassem gargarib nutrition research center, department of biochemistry and diet therapy, faculty of nutrition, tabriz university of medical sciences, tabriz, ir iran; department of biochemistry and diet therapy, faculty of nutrition, tabriz university of medical sciences, tabriz, ir iran, tel: +98-4113357580 mohammad khalili neuroscience research center, tabriz university of medical sciences, tabriz, ir iran

results based on the recent researches, certain mmps play critical role in breast cancer initiation, invasion, and metastasis. they can be regarded as predictive biomarkers of primary diagnosis and prognosis of breast cancer and have predictive value for evaluation of disease, tumor recurrence, invading of tumor cells to other sites and therapeutic outcomes. conclusions in summary, the results ...

2011
Nor Eddine Sounni Alexandra Paye Lorin Host Agnès Noël

The development of vascular system depends on the coordinated activity of a number of distinct families of molecules including growth factors and their receptors, cell adhesion molecules, extracellular matrix (ECM) molecules, and proteolytic enzymes. Matrix metalloproteases (MMPs) are a family of ECM degrading enzymes required for both physiological and pathological angiogenesis. Increasing evi...

Journal: :Journal of theoretical biology 2010
Kevin J Painter Nicola J Armstrong Jonathan A Sherratt

In this paper we consider a simple continuous model to describe cell invasion, incorporating the effects of both cell-cell adhesion and cell-matrix adhesion, along with cell growth and proteolysis by cells of the surrounding extracellular matrix (ECM). We demonstrate that the model is capable of supporting both noninvasive and invasive tumour growth according to the relative strength of cell-ce...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Amit Pathak Sanjay Kumar

Tumor invasion and metastasis are strongly regulated by biophysical interactions between tumor cells and the extracellular matrix (ECM). While the influence of ECM stiffness on cell migration, adhesion, and contractility has been extensively studied in 2D culture, extension of this concept to 3D cultures that more closely resemble tissue has proven challenging, because perturbations that change...

Journal: :International wound journal 2015
Ellie A Lenselink

Fibronectin is an adhesive molecule that plays a crucial role in wound healing, particularly in extracellular matrix (ECM) formation and also in reepithelialisation. Fibronectin plays many different roles in the wound healing process because of the presence of specific function domains and binding sites in its structure. Fibronectin interacts with different cell types, cytokines and the ECM. Th...

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