Background Chronic schizophrenia is significantly influenced by negative symptoms, with several known contributors to secondary symptoms. However, the impact of these factors and symptoms on social functioning warrants further exploration. Methods We assessed clinical antipsychotic adverse reactions, 283 hospitalized patients chronic using various standardized interviews scales. conducted multi...

BACKGROUND/AIMS The aim of this study was to clarify the effects of donepezil on extrapyramidal symptoms in patients with dementia with Lewy bodies (DLB). METHODS Using pooled datasets from phase 2 and 3, 12-week randomized, placebo-controlled trials (RCT, n = 281) and 52-week open-label long-term extension trials (OLE, n = 241) of donepezil in DLB, the effects of donepezil on the incidence o...

We report a case of pregnant woman who had been suffering from hyperemesis gravidarum presented with alteration consciousness, nystagmus, generalized weakness and extrapyramidal symptoms at 16th week gestation. Magnetic resonance imaging the brain showed typical findings Wernicke's encephalopathy extrapontine myelinolysis. The clinical features responded dramatically to high dose thiamine suppl...

OBJECTIVE Drug-induced extrapyramidal symptoms (DIEPS) often substantially compromise quality of life (QOL) of patients receiving drugs with central antidopaminergic activities. A lack of comprehensive screening method based upon patients' subjective symptoms for detecting DIEPS appears to have prevented pharmacists from delivering satisfactory pharmaceutical care for these patients. Thus, we h...

Four cases are described to demonstrate the extrapyramidal clinical syndrome sometimes appearing in chronic amphetamine users. The symptoms are dominated by choreiform or athetoid movements, ataxia and disturbances of gait. The syndrome develops during amphetamine abuse and may be observed also during abstinence. The symptoms usually disappear within a week when the drug is discontinued, but ma...