The rheological properties of wet powder masses used in the preparation of pharmaceutical pellets by extrusion/spheronization were evaluated utilizing capillary and rotational rheometers. A ram extruder was used as a capillary rheometer to construct flow and viscosity curves for each wet mass under different extrusion rates and die geometry. As a result, shear thinning behavior was observed for...

Rajesh Gandhi, PhD, is a senior research scientist in Ranbaxy Research Laboratories (Gurgaon, India), Yasvanth Ashokraj is a doctoral student, Chaman Lal Kaul, PhD, is the director of the National Institute of Pharmaceutical Education and Research (NIPER), and Ramesh Panchagnula, PhD, is a professor and head of the Department of Pharmaceutics, NIPER, Sector 67, S.A.S. Nagar (Punjab) 160062 Indi...

The aim of this study was to develop a pH responsive enteric coated extended release multiparticulate dosage form containing a model drug ketoprofen, a nonsteroidal anti-inflammatory drug used for rheumatoid arthritis. The drug loaded pellets in matrix form were prepared by using extrusion/spheronization method. The optimized pelletization method revealed that extrusion using 1 mm sieve plate a...

BACKGROUND It has previously been shown that testosterone implantation is an effective and well accepted form of androgen replacement therapy, but that pellet extrusion was the most frequent side-effect. The present study aimed to reduce the extrusion rate. OBJECTIVE To determine whether the washing of testosterone pellets to remove potentially surface-adherent particles decreased the rate of...

Testosterone replacement therapy is a treatment utilized for male hypogonadism. A subcutaneous testosterone pellet is a long-acting, slow-release delivery system that can be utilized as androgen replacement therapy. A 77-year-old man who was treated with testosterone pellets developed dermatitis consisting of erythematous plaques and patches on both buttocks and thighs within 28 days following ...