more than five hundred chemically injured patients were admitted to the labbafi-nejad medical center in spring of 1984. these patients were of two groups. the majority of patients had extensive skin burns, eye injuries as well as respiratory problems, and a second group of patients suffered mainly from neuromuscular and psychological problems. in this report, clinical manifestation and observat...

DESCRIPTION A 49-year-old man who sustained an alkali burn to both eyes after falling face first into a bucket of calcium hypochlorite solution (pH = 11.8) while cleaning his pool.

Alkali burns of the cornea may lead to permanent visual impairment or complete blindness. In the current study, the role of microRNA 296 (miR-296) was explored in mouse corneal neovascularization induced by alkali burns. An alkali burn model in Balb/c mice was developed to study chemical corneal injuries. The expression of the miR-296 gene was measured by reverse-transcription-quantitative poly...

More than five hundred chemically injured patients were admitted to the Labbafi-Nejad Medical Center in Spring of 1984. These patients were of two groups. The majority of patients had extensive skin burns, eye injuries as well as respiratory problems, and a second group of patients suffered mainly from neuromuscular and psychological problems. In this report, clinical manifestation and obs...

BACKGROUND In our earlier genome-wide association study on Stevens-Johnson Syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), we found that in Japanese patients with these severe ocular surface complications there was an association with prostaglandin E receptor 3 (EP3) gene (PTGER3) polymorphisms. We also reported that EP3 is dominantly expressed in the ocular surface-, e...

OBJECTIVE This study aims to explore the ocular surface of late stage eye burns by impression cytology (IC) and analyze the cytological changes and their relationship to ocular surface abnormalities. PATIENTS AND METHODS 68 eyes with late stage eye burns (thermal burn: 28 eyes; alkali burn: 26 eyes; acid burn: 14 eyes), procured from 68 patients (aged ranges from 17 to 70 years old). Ocular s...

A 59-year-old woman self presented to the emergency department with a painful right eye following a motor vehicle accident. She had reduced visual acuity and the eye had an alkaline pH with complete corneal uptake of fluorescein. Diagnosis of corneal abrasion and alkali burn to her right eye secondary to inflation of a driver's automobile airbag was made. The eye was irrigated with normal salin...

Chemical injuries of the eye form a small but significant fraction of ocular trauma. Three recent studies'-3 put the incidence at 7, 8-7, and 9-9% of all ocular trauma, respectively. While many of these injuries are trivial, with no lasting adverse effects, others, notably those involving strong alkalis and to a less extent acids and other noxious substances, are potentially blinding. This stud...