The prothrombinase complex converts prothrombin to α-thrombin through the intermediate meizothrombin (Mz-IIa). Both α-thrombin and Mz-IIa catalyze factor (F) XI activation to FXIa, which sustains α-thrombin production through activation of FIX. The interaction with FXI is thought to involve thrombin anion binding exosite (ABE) I. α-Thrombin can undergo additional proteolysis to β-thrombin and γ...

Objective: To develop in-situ gel formulations of Lornoxicam for sustained release to reduce the dosing frequency in treatment rheumatoid arthritis. Methods: The method ion-sensitive formation was used this study. situ were prepared by varying concentrations sodium alginate as a bio-degradable gel-forming polymer, CaCl2 cross-linking agent, and chitosan, HPMCK4, HPMCK15, guar gum, gellan xantha...

When capacity utilization is allowed to vary, standard equilibrium theory predicts that demand shocks can generate not only closed-economy business cycles that are previously thought explainable only by technology shocks, but also international business cycles that are more consistent with the data than what can be generated by technology shocks. JEL classi ̄cation: E13, E32, F11, F41.

We propose a model to study the role of industry-level external economies scale in open economies. If elasticity governing strength is below inverse trade each industry, then specialization under frictionless consistent with comparative advantage, tractable even frictions, and all countries gain from trade. External lower gains except if country specializes industries high economies, they ampli...

Australian bat lyssavirus (ABLV) is a rhabdovirus that circulates in four species of pteropid bats (ABLVp) and the yellow-bellied sheath-tailed (ABLVs) mainland Australia. In three confirmed human cases ABLV, rabies illness preceded fatality. As with virus (RABV), post-exposure prophylaxis (PEP) for potential ABLV infections consists wound cleansing, administration vaccine injection immunoglobu...

Type 1 fimbrial phase-locked mutants of uropathogenic Escherichia coli cystitis isolate F11 were used to assess the role of the invertible element during urinary tract infection. Compared to the wild type, the phase-locked off mutant was attenuated, and constitutive production of type 1 fimbriae by the phase-locked on mutant did not provide a competitive advantage.

Hydrographic and tracer [chlorofluorocarbon (CFC), component F11] data in the tropical Atlantic off Brazil taken in spring 1994 are used to describe the development of the water mass characteristics of Antarctic Bottom Water (AABW) between 10°S and 11°N. To compute the AABW transports, geostrophic computations and directly measured velocity fields are combined. Velocity profiles were measured w...