Sequence-specific DNA binding proteins must quickly bind target sequences, despite the enormously larger amount of nontarget DNA present in cells. RNA polymerases (or associated general transcription factors) are hypothesized to reach promoter sequences by facilitated diffusion (FD). In FD, a protein first binds to nontarget DNA and then reaches the target by a 1D sliding search. We tested whet...

Functional hydrogels show great potential for promoting the structural integration and signal transduction at bio/electronic interfaces.

background one of the strategies for a good outcome and pain free childbearing is to design the delivery room. objectives the aim of this study was to evaluate the effects of snoezelen room on childbearing outcome such as pain intensity, duration of labor, and perinea status in nulliparous women. patients and methods this study was a randomized controlled clinical trial consists of 100 childbea...

OBJECTIVE The aim of the paper is to offer a comprehensive approach to establishing the validity of allegations of sexual abuse by nonverbal autistic children and adults produced through facilitated communication (FC). This approach is offered as an alternative to existing methodology that relies exclusively on the "message passing" task, and has been used to advantage in the courts. METHOD T...

Multi-shelled Mn2O3 hollow microspheres have been achieved through a pH-regulated method and used as supercapacitor electrodes. The designed unique architecture allows efficient use of pseudo-capacitive Mn2O3 nanomaterials for charge storage with facilitated transport for both ions and electrons, rendering them high specific capacitance, good rate capability, and remarkable cycling performance.

OBJECTIVES To test the comparative effectiveness of 2 nonpharmacologic pain-relieving interventions administered alone or in combination across time for repeated heel sticks in preterm infants. METHODS A multicenter randomized controlled trial in 3 NICUs in Switzerland compared the effectiveness of oral sucrose, facilitated tucking (FT), and a combination of both interventions in preterm infa...