BACKGROUND Serial Analysis of Gene Expression (SAGE) is a DNA sequencing-based method for large-scale gene expression profiling that provides an alternative to microarray analysis. Most analyses of SAGE data aimed at identifying co-expressed genes have been accomplished using various versions of clustering approaches that often result in a number of false positives. PRINCIPAL FINDINGS Here we...

SAGE is an open source computer algebra system implemented using an object-oriented categorical framework, with methods for objects, methods for their elements, and methods for their morphisms. Currently, SAGE has the ability to deal with abelian groups, permutation groups, and matrix groups over a finite field. This paper will present an overview of the implementations of the group-theoretical...

Greater sage-grouse Centrocercus urophasianus (Bonaparte) currently occupy approximately half of their historical distribution across western North America. Sage-grouse are a candidate for endangered species listing due to habitat and population fragmentation coupled with inadequate regulation to control development in critical areas. Conservation planning would benefit from accurate maps delin...

The time series of differences in coincident measurements of ozone by Stratospheric Aerosol and Gas Experiment (SAGE) and by Solar Backscattered Ultraviolet (SBUV), SBUV/2, Umkehr and Microwave Limb Sounder (MLS) are analyzed, and the slopes in the differences are calculated. SAGE ozone measurements are also compared against those by HALOE. The purpose of these comparisons is to look for statis...

GENETICS, SOCIAL SCIENCES Retraction for ‘‘PKNOX2 gene is significantly associated with substance dependence in European-origin women,’’ by Xiang Chen, Kelly Cho, Burton H. Singer, and Heping Zhang, which published online August 31, 2009, in Proc Natl Acad Sci USA (10.1073/pnas.0908521106). The authors wish to retract this paper because its publication violates the Gene Environment Association ...

To comprehensively identify transcription start sites and the frequencies of individual mRNAs in human cell libraries, a method of 5' end Serial Analysis of Gene Expression (SAGE) was developed recently, which makes it possible to collect a large amount of start site information, and subsequently, we have established a related database server called 5'SAGE. This database displays the observed f...

This study investigated the functionality of the Self-Administered Gerocognitive Examination (SAGE) for cognitive screening in community settings and examined its characteristics as a cognitive screening assessment tool. From 45 community events, 1,047 individuals over age 50 were screened with SAGE. Cognitive impairment was identified in 28%. Principal-component and correlation analysis indica...

[1] We examined the consistency of time series for stratospheric ozone obtained by ozonesondes, SAGE II, HALOE, and SBUV(/2) in the northern extratropics and find excellent agreement for interannual variability and trends of ozone for 50–12.5 hPa over Europe. Ozonesonde, SAGE, and HALOE data agree well for 200 hPa–12.5 hPa. Ozone in the past few years is 6% below values in the early 1980s for 8...

Sage provides a scaled world in which real and simulated intelligence analysts work to solve realistic scenarios in innovative task environments. All aspects of Sage are instrumented for data collection and Sage itself is built to facilitate the swapping in and out of prototypes of innovative tools for information search, hypothesis generation, and hypothesis testing. Sage focuses not simply on...

Organophosphate resistant and susceptible tick larvae from laboratory strains of the southern cattle tick, Rhipicephalus (Boophilus) microplus were exposed to low doses of the organophosphate (OP) acaricide, coumaphos. Serial analysis of gene expression (SAGE) was used to analyse differential gene expression in response to OP treatment and to compare the responses of OP-treated and -untreated r...