نتایج جستجو برای: factor vii

تعداد نتایج: 864410  

Journal: :The Journal of biological chemistry 1976
R Radcliffe Y Nemerson

Coagulation Factor VII from bovine plasma is a glycoprotein containing a single peptide chain. The NH2-terminal sequence of Ala-Asx-Gly-Phe-Leu- is homologous with the NH2 termini of prothrombin, Factor IX, and the light chain of Factor X. Factor Xa in the presence of calcium ions and phospholipid cleaves Factor VII at an Arg-Ile bond in the sequence Arg-Ile-Val-Gly-Gly-, producing a two-chain ...

Journal: :Journal of thrombosis and haemostasis : JTH 2005
C H Martini C J M Doggen C Cavallini F R Rosendaal P M Mannucci

Bretaudiere J. Factor VII gene intronic mutation in a lethal Factor VII deficiency: effects on splice-site selection. Blood 2003; 102: 561–3. 10 Rosen E, Chan JCY, Idusogie E, Clotman F, Vlasuk G, Luther T, Jalbert LR, Albrecht S, Zhong L, Lissens A, Schoonjans L, Collen D, Costellino FJ, Carmeliet P. Mice lacking Factor VII develop normally but suffer fatal perinatal bleeding. Nature 1997; 390...

2005
Anne Helen Skartlien Sissel Lyberg-Beckmann Ingar Holme Ingvar Hjermann Hans Prydz

Clotting Factor VII activity emerges as a highly significant predictive factor for development of cardiovascular disease (CVD) In prospective trials. We have previously shown that In hypertriglyceridemlc Individuals a fraction of their clotting Factor VII molecules is present in an activated state In phosphollpase C-sensitive complexes in plasma. These complexes may explain the increased Factor...

Journal: :Arteriosclerosis 1989
A H Skartlien S Lyberg-Beckmann I Holme I Hjermann H Prydz

Clotting Factor VII activity emerges as a highly significant predictive factor for development of cardiovascular disease (CVD) in prospective trials. We have previously shown that in hypertriglyceridemic individuals a fraction of their clotting Factor VII molecules is present in an activated state in phospholipase C-sensitive complexes in plasma. These complexes may explain the increased Factor...

Journal: :The Journal of clinical investigation 1982
G J Broze

Human coagulation Factors VII and VIIa bind with equal affinity to monocytes stimulated with endotoxin. Equilibrium binding studies performed at 0 degrees C using 125I-labeled Factor VII and VIIa showed the dissociation constant (Kd) to be congruent to 82 pM with congruent to 3,600 binding sites/monocyte. Ca++ was required for Factor VII and VIIa interaction with monocytes (optimal CaC12 concen...

Journal: :Blood 1997
A A Arbini E S Pollak J K Bayleran K A High K A Bauer

Although small deletions, splice site abnormalities, missense, and nonsense mutations have been identified in patients with factor VII deficiency, there have been no reports of mutations in the factor VII promoter. We investigated a girl with factor VII levels that were less than 1% of normal in association with a severe bleeding diathesis. The patient is homozygous for a T to G transversion th...

Journal: :Blood 1992
P Wildgoose Y Nemerson L L Hansen F E Nielsen S Glazer U Hedner

Previous results, presented in abstract form, indicate that replacement of thromboplastin with a mixture of phospholipid and truncated soluble tissue factor apoprotein results in a coagulation assay that can directly measure plasma factor VIIa levels without interference from zymogen factor VII (Atherosclerosis Thromb 11:1544a, 1991 [abstr]). We have exploited the specificity and sensitivity of...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
J Sheehan M Templer M Gregory R Hanumanthaiah D Troyer T Phan B Thankavel P Jagadeeswaran

It is not known whether the mammalian mechanism of coagulation initiation is conserved in fish. Identification of factor VII is critical in providing evidence for such a mechanism. A cDNA was cloned from a zebrafish (teleost) library that predicted a protein with sequence similarity to human factor VII. Factor VII was shown to be present in zebrafish blood and liver by Western blot analysis and...

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