Factor XIII and fibrinogen are unusual among clotting factors in that neither is a serine protease. Fibrin is the main protein constituent of the blood clot, which is stabilized by factor XIIIa through an amide or isopeptide bond that ligates adjacent fibrin monomers. Many of the structural and functional features of factor XIII and fibrin(ogen) have been elucidated by protein and gene analysis...

Fibrinogen and factor XIII were measured in sixty-four women with recently detected gynaecological tumours. Twenty-six of these tumours were benign and 32 were malignant: of the last group, nine patients had metastases. No patient showed clinical signs of bleeding or thrombosis. A reference group consisted of 31 age-matched healthy women. For fibrinogen, no significant deviation between the pat...

INTRODUCTION The objective of this study was to determine the effects of the administration of the coagulation factor XIII (F XIII) on intestinal functional capillary density, leukocyte adherence and mesenteric plasma extravasation during experimental endotoxemia. METHODS In a prospective, randomized, controlled animal study 42 male Wistar rats were divided into three groups. Group 1 served a...

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In this study a previously undescribed 3 bp deletion, AAT1030-1032, in the factor XIII A subunit gene, has been detected in a Thai patient. The inframe deletion results in the translation of a factor XIII A subunit that lacks Asn344. This is the first inframe deletion to be identified in the factor XIII A subunit gene because six previously reported deletions have all caused frameshifts. The de...

After fibrin polymerization, activated Factor XIII catalyzes the formation of intermolecular cross-links between '-ychain pairs and also among two or more a-chains to form polymers. In this report we characterize the size and heterogeneity of a-chain polymers, establish the role of high concentrations of Factor XIII in determining the extent and rate of a-polymer formation, and also provide evi...

BACKGROUND Factor XIII plays an important role in the stabilization of the linkage between fibrins and in the pathophysiology of coronary artery disease (CAD). The association between factor XIII Val34Leu polymorphism and CAD risk remains controversial. METHODS We conducted a meta-analysis of 36 studies involving 26,940 cases and 34,694 controls. Subgroup analyses were performed with division...

We have shown an association between a common mutation in the factor XIII a-subunit gene, coding for an amino acid change, 3 amino acids from the thrombin activation site (factor XIII Val34Leu) that may protect against myocardial infarction and predisposes to intracranial hemorrhage. To investigate the possible role of factor XIII Val34Leu in the pathogenesis of venous thromboembolism (VTE) and...

The spatial variations of the pair amplitude, and the local density of states in d-wave or s-wave superconductor-ferromagnet hybrid structures are calculated self consistently using the Bogoliubov-deGennes formalism within the two dimensional extended Hubbard model. We describe the proximity effect in superconductor / ferromagnet (SF) bilayers, FSF trilayers, and interfaces between a supercondu...